Autoimmune disease Flashcards
1
Q
innate immune system
A
first line defence
physical & chemical barriers
2
Q
adaptive immune system
A
slower to adapt has memory of previous infection cell mediated: CD4, CD8 attack microorganisms inside cells humoral: b-lymphocytes and antibodies attack outside cells
3
Q
tolerance to self antigens
A
selection and deletion of lymphocytes that react to self
failure of this mechanism leads to autoimmune conditions
4
Q
central tolerance
A
positive and negative selection
5
Q
classification
A
gel coombs type 1: type 2: IgG/IgM binding to protein in surface of own cell type 3: type 4:
6
Q
classification
A
gel coombs
type 1: IgE mediated, allergy/anaphylaxis
type 2: IgG/IgM binding to protein in surface of own cell
type 3: immune complex mediated
type 4:
7
Q
goodpasture’s (type 2)
A
antibodies against type IV collagen
8
Q
SLE (type 3)
A
tested for with ANA (antinuclear antibody) test
9
Q
SLE (type 3)
A
tested for with ANA (antinuclear antibody) test
