Autoantibodies and associated disorder

Question 1

Anti-ACh receptor

Answer 1

Myasthenia gravis

Question 2

Anti-Basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin, Lupus anticoagulant

Answer 3

SLE, antiphospholipid syndrome

Question 4

Anticentromere

Answer 4

CREST syndrome (limited scleroderma)

Question 5

Anti-desmoglein

Answer 5

Pemphigus vulgaris

Question 6

Anti-dsDNA

Answer 6

SLE

Question 7

Anti-Smith

Answer 7

SLE

Question 8

Anti-glutamate decarboxylase

Answer 8

Type 1 diabetes mellitus

Question 9

Anti-hemidesmosome

Answer 9

Bullous pemphigoid

Question 10

Antihistone

Answer 10

Drug-induced Lupus

Question 11

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 11

Polymyositis, dermatomyositis

Question 12

Antimicrosomal, Antithyroglobulin, Anti-TPO

Answer 12

Hashimoto thyroiditis

Question 13

Antimitochondrial

Answer 13

Primary biliary cirrhosis

Question 14

Antinuclear antibody (ANA)

Answer 14

SLE, nonspecific

Question 15

Anti-Scl-70 (anti-DNA topo I)

Answer 15

Diffuse Scleroderma

Question 16

Anti-Smooth muscle

Answer 16

Autoimmune hepatitis

Question 17

Anti-SSA (anti-Ro)

Answer 17

Sjogren syndrome

Question 18

Anti-SSB (anti-La)

Answer 18

Sjogren syndrome

Question 19

Anti-TSH receptor

Answer 19

Graves dz

Question 20

Anti-U1 RNP (ribonucleoprotein)

Answer 20

Mixed connective tissue dz

Question 21

c-ANCA (PR3-ANCA)

Answer 21

Granulomatosis w/ polyangiitis (Wegener)

Question 22

IgA antiendomysial, IgA anti-tissue transglutaminase

Answer 22

Celiac dz

Question 23

p-ANCA (MPO-ANCA)

Answer 23

Microscopic polyangiitis, Churg-Strauss syndrome

Question 24

Rheumatoid factor (Ab, most commonly IgM, specific to IgG Fc region)

Answer 24

RA

Question 25

Anti-CCP

Answer 25

RA