Auto-antibodies

Question 1

Raised in RA

Answer 1

Anti-CCP specific

RF sensitive

Question 2

Raised in systemic sclerosis

Answer 2

ANA
Anti-centromere antibodies
RF

Question 3

Raised in SLE

Answer 3

ANA (>90%)
Anti-dsDNA (very specific)
Anti-extractable nuclear antigens: anti-smith, anti-Ro, anti-La, anti-RNP
Antiphospholipid antibodies
RF
Antihistone antibodies in drug induced

Question 4

What conditions raise cANCA and pANCA

Answer 4

Cytoplasmic: Wegener’s granulomatosis, PAN

Peripheral: Churg-Strauss, pulmonary vasculitis and renal vasculitis including Goodpastures

Question 5

What conditions raise thyroid peroxidase antibodies

Answer 5

Hashimotos (>85%)

Graves (>50%)

Question 6

Raised in Primary biliary cirrhosis

Answer 6

Antimitochondrial antibodies (>95%)
Anti-smooth muscle antibodies (50%)

Question 7

Raised in pernicious anaemia

Answer 7

Parietal cell antibodies (>90%)

Intrinsic factor antibodies (50%)