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DIG Biweekly 2 > Audia: Hepatitis ILA > Flashcards

Audia: Hepatitis ILA Flashcards

1
Q

the major problem for viral hepatitis

A

chronic liver disease and HCC

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2
Q

picornavirus
acute diease

A

HAV (Hep A virus)

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3
Q

2 enteric acute diseases

A

HAV and HEV

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4
Q

hepadnavirus
acute
chronic/cancer

A

HBV (hep B virus)

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5
Q

flavivirus (RNA)
acute, chronic/cancer

A

HCV

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6
Q

RNA virus
co-infection with HBV
chronic/fulminant

A

HDV

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7
Q

oral-fecal transmission
infectious hepatitis
NO chronic or carrier state

A

Hepatitis A

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8
Q

2-4 wk incubation (IgM then IgG)

A

Hepatitis A

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9
Q

naked capsid
+ssRNA

A

HAV

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10
Q

replication of HAV:

A

receptor mediated endocytosis
uncoat and RNA released in cytoplasm
single polyprotein made and chopped up by protease into functional subunits

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11
Q

type of virus that is ready to be translated once it gets into host cell cytoplasm

A

+ssRNA

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12
Q

extremely stable due to no envelope

A

Hep A

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13
Q

sx’s of fever, fatigue, nausea, abd pain occur abruptly

A

Hep A

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14
Q

incubation period is average of 30 days

A

Hep A

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15
Q

can see jaundice within 2-4 wks as compared to hep B 1-6 months

A

Hep A

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16
Q

close personal contact
contaminated food/water (shellfish)!
blood exposure (rare)

A

Hep A

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17
Q

to dx:
time course of sx’s
identify source
serology

A

Hep A

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18
Q

best way to prevent Hep A

A

vaccine

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19
Q

hepadnavirus
spreads by blood/bodily fluids

A

Hep B

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20
Q

can lead to chronic disease and HCC

A

Hep B

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21
Q

“serum hepatitis”

A

Hep B

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22
Q

enveloped virus
dsDNA genome
has surface Ag

A

Hep B

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23
Q

surface antigen for Hep B that actually breaks off as well with the Hep B virus from host cell and acts as decoy to host Ab’s so Hep B can prevail

A

HBsAg

24
Q

surface antigen used for HBV vaccine

A

HBsAg

25
Q

soluble antigen of HBV and associated with replication

A

HBeAg

26
Q

core antigen that will bind with host Ab and indicate carrier/chronic infection

A

HBcAg

27
Q

Hep B replication

A

into host cell (becomes a part of host genome)
uncoat
reverse transcriptase
makes more virus
HBV and HBsAg released

28
Q

how do people become carriers of Hep B

A

if exposed and have weak T cell response (mild sx’s but won’t clear virus)

29
Q

jaundice from liver damage 1-6 months post infection

A

Hep B

30
Q

10% of these cases become chronic (cirrhosis)

A

Hep B

31
Q

____% of cases of HCC have viral cause

A

80%

32
Q

long incubation (3 months ave)
insidious onset
prodromal phase

A

Hep B acute infection

33
Q

classic icteric sx’s of liver damage

A

jaundice, dark urine, pale stool

34
Q

fulminant disease of HBV when co-infected with what

A

HDV

35
Q

what type of hypersensitivity rxns can be associated with Hep B

A

type III (immune complexes)

36
Q

detected by liver enzymes

A

Hep B chronic infection

37
Q

____% of patients develop cirrhosis or liver failure

A

10%

38
Q

80% of all HCC is due to what

A

HBV

39
Q

HBV has integration of viral genome into what

A

host hepatocyte DNA

40
Q

Hep B transmission

A

sexual
parenteral
perinatal

41
Q

Dx w/ clinical sx’s
elevated liver enzymes
serology and virus proteins

A

Hep B

42
Q

Rx/prevent Hep B

A

HBsAg Hep B vaccine

43
Q

ssRNA
requires co-infection with HBV

A

HDV (Hep D)

44
Q

host RNAPII makes RNA copy
replicates genome, makes mRNA
genome is ribozyme

A

replication for Hep D

45
Q

blood/bodily fluids transmission
co-infection

A

Hep D

46
Q

Dx Hep D

A

ELISA for delta Ag or Ab

47
Q

flavivirus
difficult to culture
1-6 month incubation period
can cause chronic disease

A

Hep C

48
Q

+RNA genome
enveloped

A

Hep C

49
Q

how to make drugs against viruses

A

selective toxicity

50
Q

Hep C replication:

A

Bind to receptor and gets in by endocytosis
Endosome w/ lysosome and pH drops and helps un-coat and release ribonucleic acid into cytoplasm
Replicate and make polyproteins—–then chopped up by protease to make functional pieces
Leave host cell through exocytosis

51
Q

main mechanism of immune avoidance for Hep C

A

antigenic drift (error prone replication and causes mutations)

52
Q

____ are the reservoirs for HCV

A

humans

53
Q

Ab to HCV not protective why

A

antigenic drift

54
Q

60-85% likelihood of chronic infection

A

Hep C

55
Q

no vaccine for this

A

Hep C

56
Q

dx by ELISA

A

hep C

57
Q

_____ has to have an external coat of Hep B before it can infect hepatocytes and multiply

A

Hep D

DIG Biweekly 2 (11 decks)

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