aubf 1 (3rd ppt) Flashcards
Made up of Tamm-Horsfall Protein/uromodulin-a
glycoprotein produced by the RTE cells (kidney)
CASTS
may result from tubular
distension or, in the case of extreme urine stasis, from
formation in the collecting ducts.
broad cast
pertains to the presence of urinary casts
cylinduria
Sternheimer-Malbin stain produces a __ color in
hyaline casts.
pink
colorless and homogenous matrix
hyaline cast
Casts laden with cells such as RBCs, WBcs, epithelial cells
and bacteria
CELLULAR CASTS
s is much more specific, showing bleeding
within the nephron.
RBC CAST
Primarily associated with damage to the glomerulus
(glomerulonephritis) that allows passage of the cells
through the glomerular membrane
CELLULAR CAST
ORANGE RED COLOR, cast matrix containing rbc
rbc cast
signifies
infection or inflammation within the nephron
WBC cast
primary marker for
distinguishing pyelonephritis (upper UTI) from
cystitis (lower UTI)
wBC cast
wbc cast is primary marker for
distinguishing
pyelonephritis (upper UTI) from
cystitis (lower UTI)
composed of neutrophils;
therefore, they may appear granular, and,
unless disintegration has occurred, multilobed
nuclei will be present
wbc cast
cast matrix containing WBC
wbc cast
casts containing bacilli both within and bound
to the protein matrix are seen in
pyelonephritis
bacterial cast
bacilli bound to protein matrix
bacterial cast
Casts containing RTE cells represent the presence of
advanced tubular destruction, producing urinary stasis
along with disruption of the tubular linings.
EPITHELIAL CELL CASTS
most frequently encountered
include RBC and WBC casts in glomerulonephritis and
WBC and RTE cell casts, or WBC and bacterial casts
in pyelonephritis.
mixed cellular cast
RTE cells attached to protein matrox
epithelial cell cast
seen in conjunction with oval fat bodies and free fat
droplets in disorders causing lipiduria
fatty cast
These are highly refractile under bright-field
microscopy.
fatty cast
fat droplets and oval fat attached to protein matrix
fatty cast
coarse and fine granules in cast matrix
granular cast
seen in conjunction with WBC casts
contain WBC granules of varying sizes
granular cast
representative of extreme urine stasis, indicating chronic
renal failure
waxy cast
waxy cast stain and color
supravital stain - dark pink
cast with jagged ends and notches
waxy cast
indicates destruction
(widening) of the tubular walls. Also, when the flow of urine
to the larger collecting ducts becomes severely
compromised, casts form in this area and appear broad.
broad cast
wider than normal cast
broad cast
is to detect the presence of the relatively few abnormal
types that may represent such disorders as liver
disease, inborn errors of metabolism, or renal damage
caused by crystallization of medications compounds
within the tubules
urinary crystal
