Asthma Flashcards

1
Q

When is the peak age of presentation for asthma?

A
  • 3 y/o
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2
Q

What is the strongest predisposing factor for developing asthma?

A
  • atopy/allergic triad
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3
Q

What are principal allergens of asthma?

A
  • dust mite
  • animal dander
  • cockroach
  • grass & tree pollen
  • alternaria (a soil mold)
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4
Q

What are the etiologies of asthma?

A
  • hygiene hypothesis
  • diet
  • air pollution
  • allergens
  • occupational exposures
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5
Q

Describe the pathology of asthma

A
  • REVERSIBLE*
  • shedding of airway epithelium
  • edema
  • mucus plugging
  • mast cell activation
  • collagen deposition under the basement membrane
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6
Q

T/F: Over time, asthmatics incur permanent physiologic changes.

A
  • True
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7
Q

Airflow is _______ proportionate to the ______ of the airway.

A
  • inversely

- radius

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8
Q

What must be done to determine a definitive diagnosis of asthma?

A
  • spirometry in pts older than 4
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9
Q

What are the symptoms of asthma?

A
  • wheezing
  • cough worse @ pm
  • recurrent difficulty breathing
  • chest tightness
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10
Q

T/F: A lack of wheezing and a normal chest exam do not exclude asthma.

A
  • True
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11
Q

When do asthma symptoms occur or worsen?

A
  • exercise
  • inhalant allergens
  • irritants
  • changes in weather
  • strong emotional response
  • stress
  • menstrual cycles
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12
Q

What are signs of severe asthma?

A
  • hypoxemia
  • hypercapnia
  • pulsus paradoxus
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13
Q

T/F: CXR is always indicated in asthma r/o

A
  • False, not routinely indicated
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14
Q

What is the hallmark of asthma?

A
  • bronchial hyper-responsiveness
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15
Q

What are tests that can be done for an asthma dx?

A
  • methocholine challenge
  • spirometry
  • labs
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16
Q

Describe spirometry values for an obstructive dz

A
  • FVC normal or decreased
  • FEV1 decreased by < 80%
  • FEV1/FVC decreased by <70%
17
Q

Describe spirometry values for a restrictive dx

A
  • FVC decreased by <80%
  • FEV1 decreased
  • FEV1/FVC normal
18
Q

When is stridor heard, inspiration or expiration? wheeze?

A
  • stridor = inspiration

- wheeze = expiration

19
Q

What is the goal of asthma therapy?

A
  • reduce impairment

- reduce risk

20
Q

What is the stepwise management of asthma?

A
  • SABA
  • LABA
  • ICS
  • LTR
  • cromolyn
  • theophylline
  • oral steroid
  • zileuton
  • omalizumab
21
Q

What are adrenergic beta-agonists?

A
  • rescue inhalers
22
Q

What is the effect of adrenergic beta-agonists on airways?

A
  • relaxation of airway smooth m.
  • increase mucocilliary clearance & mucus secretion
  • decrease cough
  • no effect on chronic inflam