Assisted Repro Techniques Flashcards
Artificial Insemination
deposit collected sperm sample into vagina/cervix through catheter
for those with: no sperm, low sperm density or motility, unexplained infertility
IVF
fertilisation of egg outside the body and reimplantation into uterus
12 eggs retrieved per cycle
risks: multiple pregnancies, hyper stimulation syndrome, increased hydrospadias occurs in boys
Male sub fertility is explained by:
deficiencies in ejaculate volume, sperm concentration, azoospermia, poor sperm motility, abnormal sperm morphology, deficient in sperm signalling proteins
Ovulation Defect
no oocytes releases, assoc with PCOS
characterised by: hirsutism, obesity, oligomenorrhea, infertility
Ovulation Induction Medication is associated with:
multiple pregnancy risks, thickened cervical mucous and vaginal dryness, hot flushes and nausea, ovarian cyst formation, increased breast tenderness, skin rashes and bloating, increased miscarriage risk
Unexplained Infertility
duration of infertility greater than 1 year
Workup: history, physical exam, 3 semen analysis, laparoscopy, mid luteal progesterone estimation, hormone profile, post coital test, hystersalpinogram
Newer Techniques
intra peritoneal insemination - inject sperm directly into fallopian tubes
fallopian tube sperm perfusion - constant perfusion of fallopian tube with sperm
Immunological Infertility
possible mechanism: gamete destruction by anti sperm antibodies or anti ovary antibodies
inhibition of ZP binding by anti sperm antibodies
Endometriosis
presence of functioning endometrial tissue outside the uterus
poor environment therefore poor sperm function
Tubual disease
torsion causes tissues to necrose as blood flow is occluded
all women have surgery before IVF
Embryo Implantation
enhancing embryonic viability after IVF
occurs by: zonal drilling, identification of biochemical markers for receptivity
