aspirin

Question 1

aspirin

Answer 1

• mild analgesic
• prevents stimulations of nerve endings at site of pain and inhibits release of prostagladins at site of injury
• anti-pyretic
• relieves flammatory response
• non narcotic

Question 2

mild analgesic

Answer 2

block sensation of pain at the source

Question 3

original development of aspirin

Answer 3

• hippocrates used chewing willow bark, which had salicylic acid as active ingredient

Question 4

what reaction synthesizes aspirin

Answer 4

a esterification reaction (condensation reaction)

Question 5

how is aspirin synthesized

Answer 5

• by reacting salicylic acid with ethanoic anhydride to produce aspirin and ethanoic acid
• mixture is warmed gently aspirin is isolated; chrystals form and then suction filtered and washed with chilled water
• aspirin is purified by recrystalizzation (impure chrystals are warmed in hot thanol; solution cooled and separated by filtration)
• melting point determination is used to determin the purity of the produced aspirin

Question 6

physiological effect of aspirin

Answer 6

• anticoagulant (reduces blot clotting)
• antipyretic
• anti-inflammatory
• prophylatic; taken to prevent, not in response
• however does have SYNERGIC effect

Question 7

modification of aspirin

Answer 7

• for absorbtion
• for distribution
• to increase bioavalibility, solubility has to be increased
• aspirin is reacted with a alkaline (NaOh or NaHCO3 to form ionic salt)