Appetite regulation and obesity Lecture reading week/lecture 1 Flashcards

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1
Q

link between homeostasis and hunger (Wynne et al., 2005)

A
  • Hypothalamus, brainstem and reward centres use neuropeptides to signal the regulation of energy homeostasis.
    • Insulin and hormones synthesised by adipose tissue reflect long term nutritional status of the body and influence these circuits.
    • Circulating gut hormones modulate these pathways and result in appetite stimulation or satiety effects.
    • Loss of homeostatic process may result in obesity
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2
Q

link between homeostasis and hunger (Abdalla, 2017)

A
  • Maintenance of a stable body weight determinant in survival.
    • Food intake is controlled by the hypothalamus, the brainstem, and endocannabinoids and peripherally by the satiety and adiposity signals
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3
Q

Geracioti & Liddle (1988): blunted CCK release in response to a test meal in BN (delayed satiety)
- link to CCK
- Treatment

A
  • BN = bulimia nervosa
    • Integrated plasma CCK response to eating and postprandial satiety were significantly impaired in people with bulimia compared with controls.
    • Abnormalities may be improved by treatment with tricyclic antidepressants
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4
Q

leptin resistance mice study (2018) - link to obesity

A
  • Destructive mechanism blocks brain from knowing when to stop eating.
    • Leptin resistance
    • Mice study
    • This may cause obesity
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5
Q

satiation (Le Magnen, 1992)

A
  • Satiation determines meal size
    • Food reward has been attributed to satiating actions of nutrients
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