AP02 - Cartilage and bones Flashcards

1
Q

What are the three types of cartilage?

A
  1. Hyaline
  2. Elastic
  3. Fibrous
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2
Q

What are the main cell types in cartilage?

A

Chondrocytes

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3
Q

Where is the location of collagen fibre type 1?

A
  • Bone
  • Skin
  • Dentin
  • Cornea
  • BV
  • Fibrocartilage
  • Tendon
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4
Q

Where is the location of collagen fibre type 2?

A

Cartilaginous tissues

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5
Q

Where is the location of collagen fibre type 3?

A
  • Skin
  • Ligaments
  • BV
  • Internal organs
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6
Q

Where is the location of collagen fibre type 4?

A
  • B. memb in various tissues
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7
Q

Where is the location of collagen fibre type 5?

A
  • BV wall
  • Synovium
  • Corneal stoma
  • Tendon
  • Lung
  • Bone
  • Cartilage
  • Skeletal muscle
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8
Q

Describe the structure/ appearance of hyaline cartilage?

A
  • Matrix contains moderate amount of collagen fibres
  • Glassy appearance in living tissue
  • Highly hydrated nature of the ground substance which consists of 3 types of GLYCOSAMINOGLYCANS
  • Almost friction free surface (low coefficient of friction)
  • Shock absorber
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9
Q

Describe the structure/ appearance of elastic cartilage?

A
  • Matrix contains collagen fibres along with a large number of elastic fibres
  • Elastic fibre netwrorks and collagen type II fibres
  • Principal protein is elastin
  • Springy and yellow
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10
Q

Describe the structure/ appearance of fibrous cartilage?

A
  • Matrix contains limited number of cells and ground substance amidst a substantial amount of collagen fibres
  • Tough and v strong
  • Contains cartilage ground substance and chondrocytes
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11
Q

What are the three types of glycosaminoglycans found in hyaline cartilage?

A
  1. Hyaluronic acid
  2. Chondroitin sulphate
  3. Keratin sulphate
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12
Q

Where can hyaline cartilage be found?

A
  • Embryonic skeleton
  • Costal cartilages
  • Cartilage of the nose, trachea, lining of the ends of some bones and larynx
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13
Q

Where can elastic cartilage be found?

A

Found in the internal support of the external ear and epiglottis

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14
Q

Where can fibrous cartilage (fibrocartilage) be found?

A

Found in the intervertebral discs and pubic symphysis

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15
Q

What is cartilage?

A
  • Avascular form of CT
  • Consists of extracellular fibres embedded in a matrix that contains cells localised in small cavities
  • Amount and kind of extracellular fibres in the matrix varies depending on type of cartilage
  • Nourished by diffusion
  • No BV/ lymphatics or nerves
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16
Q

What are the functions of cartilage?

A
  1. Support soft tissues
  2. Provide a smooth, gliding surface for bone articulation at joints
  3. Enable the development and growth of long bones
17
Q

What are the functions of bone?

A
  1. Supportive structures for the body
  2. Protectors of vital organs
  3. Reservoirs of calcium and phosphorus
  4. Levers on which muscles act to prod movement
  5. Containers for blood producing cells
18
Q

What are the different types of bone?

A
  1. Compact (trabecular)

2. Spongy (cancellous)

19
Q

What are the different classifications of bone?

A
  1. Long bones
  2. Short bones
  3. Flat bones
  4. Irregular bones
  5. Sesamoid bones
20
Q

What are the characteristics of compact bone?

A
  • Dense
21
Q

What are the characteristics of spongy bone?

A
  • Spicules of bone enclosing cavities containing blood forming cells (marrow)
22
Q

Example of long bone?

A
  • Humerus in upper limb

- Femur in lower limb

23
Q

Example of short bone?

A

Bones of wrist and ankle

24
Q

Example of irregular bone?

A

Bones of face

25
Q

Example of flat bone?

A

Skull

26
Q

What is the typical shape of long bones?

A

Tubular

27
Q

What is the typical shape of short bones?

A

Cuboidal

28
Q

What is the typical shape of irregular bones?

A

Bones with various shapes

29
Q

What is the typical shape of flat bones?

A

Consist of two compact

bone plates separated by spongy bone

30
Q

What is the typical shape of sesamoid bones?

A

Round or oval bones that develop in tendons

31
Q

What are the different types of osteogenesis (bone development)?

A
  1. Intramembranous ossification

2. Endochondral ossification

32
Q

What is intramembranous ossification?

A
  • Process of bone development from fibrous membranes
  • Osteoblasts differentiate directly from mesenchyme and begin secreting osteoid
  • Begins as mesenchymal cells form a template of the future bone
33
Q

What is endochondral ossification?

A
  • Process of bone development from hyaline cartilage

- Pre-existing matrix of hyaline cartilage is eroded and invaded by osteoblasts, which then begin osteoid production

34
Q

Which bone undergoes intramembranous ossification?

A

Formation of flat bones in skull, the mandible and clavicles

35
Q

Which bone undergoes endochondral ossification?

A

All bones of body except bones involved in intramembranous ossification