Aortic Stenosis Flashcards
What are the levels of AS obstruction and their causes?
- Supravalvular - membrane, shelf in AO
- Valvular - calcific, congenital, rheumatic
- Subvalvular - Membrane, muscular IVS
What are the 3 ways to calculate pressure gradients?
- Instantaneous - single point in time
- Peak to peak - two points in time
- Mean - Average
What is the formula for Mean/Average pressure gradient?
Pmean = 2.4 x (Vmax)^2
Describe the effect of AS effect on the LV? (4 steps)
- AS obstruction increases afterload
- LV systolic pressure increases
- Force of contraction increases
- LV concentric hypertrophy due to pressure overload
What does AS lead to?
CHF
How does AS lead to CHF? (7 steps)
- SV decreases
- Afterload increases
- LV stiffness and compliance increase
- LV filling pressures increase
- LA size and pressure increase
- Pulmonary congestion
- RV failure
What are the inter-leaflet triangles and what are the names?
Extensions of the LVOT that extend up to the STJ and provide a smooth surface for blood flow.
- R/L coronary interleaflet triangle
- R/Non coronary interleaflet triangle
- Non/L coronary interleaflet triangle
How does ASE recommend measuring the aorta?
Leading to leading at the sinus, STJ and ascending aorta
How can you find the change in pressure between the LV and AO with Bernoulli?
Change in P = 4(V2^2 - V1^2)
Or
Change in P = 4V^2
What are the symptoms of AS? (6)
- SOBOE
- Fatigue
- Chest pain/Palpitations
- Arrhythmias
- Dizziness/Syncope
- Signs of CHF (edema etc.)
What are the clinical signs of AS? (4)
- Auscultation
- Angina Pectoris
- Presyncope/Syncope
- CHF
What auscultation may be heard with AS and where?
- Harsh ejection murmur
- AO regurgitation murmur (if regurg is present)
Heard in right upper sternal border
Why does AS cause Angina Pectoris? (3)
- Reduced coronary artery profusion
- LV hypertrophy (more muscle = more O2 demand and more pressure)
- Increased contraction and decreased relaxation causes compression of the intramyocardial arteries
Why does AS cause Presyncope/Syncope?
Reduced cerebral perfusion with exertion.
What is the most common order of AS etiology in patients > 70 years?
- Calcific/Degenerative
- Congenital/Bicuspid
- Rheumatic
Where does thickening start with calcific AS?
Underside of cusps/commissures
Where does thickening start with rheumatic AS?
Free edges/tips of the cusps
What are 3 types of congenital AS?
Bicuspid, Unicuspid, Quadricuspid
What is the most common order of AS etiology in patients < 70 years?
- Congenital/Bicuspid
- Rheumatic
- Calcific/Degenerative
How often does aortic sclerosis develop into AS?
10-15%