Aortic dissection Flashcards
A patient presents with sudden severe tearing chest pain that radiates to the back. There is a difference between the right and left arm systolic blood pressures of greater than 20 mmHg. A chest x-ray shows a widened mediastinum, what is the likely diagnosis?
Aortic dissection.
What is the primary mechanism of aortic dissection?
Separation of the layers of the aortic wall due to an intimal tear.
What are the Stanford subtypes of aortic dissection?
Stanford Type A involves the ascending aorta or arch. Stanford Type B involves the descending aorta distal to the subclavian artery.
What are common risk factors for aortic dissection?
- Aortic damage (e.g., hypertension, thoracic aneurysm, atherosclerosis)
- Marfan’s syndrome
- Ehlers-Danlos syndrome
- Congenital bicuspid aortic valve
- Turner’s syndrome
- syphilis aortitis
What large-vessel vasculitis can cause aortic dissection, particularly in the elderly?
Giant cell arteritis is a large-vessel vasculitis that predominantly affects the aorta and its major branches. Chronic inflammation from GCA can weaken the aortic wall, leading to aneurysms, dissections, or rupture. The inflammation compromises the structural integrity of the intima and media layers, predisposing the aorta to tears.
What large-vessel vasculitis can cause aortic dissection, particularly in females of Asian descent?
Takayasu arteritis primarily affects large vessels, specifically the aorta and its major branches (e.g., subclavian, carotid, and renal arteries). It leads to inflammation of the vessel walls, which can result in stenosis, occlusion, aneurysm formation, and, in rare cases, aortic dissection. The condition predominantly occurs in young women, particularly of Asian descent, and presents with symptoms like claudication, diminished pulses (“pulseless disease”), and arterial bruits.
What is the most common cause for aortic dissection, is it hypertension or is it atherosclerosis?
Hypertension is the leading risk factor because it increases shear stress on the aortic wall, predisposing it to intimal tears. Over time, the high blood pressure weakens the aortic wall, particularly at points of stress, such as near the aortic arch or ascending aorta, which are more prone to dissection. This explains why hypertension is so commonly associated with both Stanford Type A and Type B dissections. While atherosclerosis is a contributing factor to many vascular conditions and can weaken the aortic wall, it is not the primary cause of aortic dissection. Instead, it is more strongly associated with aneurysms rather than acute dissections. Atherosclerosis can, however, exacerbate pre-existing conditions or contribute to chronic damage, making the aorta more susceptible to a dissection triggered by hypertension or other stressors. This is commonly seen in elderly patients where there’s a medial degeneration of aorta with basophilic ground substance.
What traumatic event can lead to aortic dissection?
Blunt chest trauma, such as from a motor vehicle accident, can cause aortic dissection due to the rupture of the ligamentum arteriosum. These are often fatal. The most common cause of sudden death after a steering wheel injury from motor vehicle accident is aortic injury.
What is the most common cause of sudden death following a motor vehicle accident, and what are the other potential causes?
The most common cause of sudden death after a steering wheel injury from motor vehicle accident is aortic injury.
- Tension pneumothorax is a life-threatening condition that may result in cardiovascular collapse; however, the resulting death is not usually instantaneous.
- Abdominal injury may result in profound shock if rapid internal bleeding occurs.
- Cardiac contusion produces sudden death when the injury involves the cardiac chambers or vessels.
- Cervical spine injury leads to quadriparesis and sometimes respiratory paralysis.
What are the hallmark symptoms of aortic dissection?
Severe chest pain radiating to the back with a ‘tearing’ quality and asymmetric blood pressure (>20 mmHg difference).
What findings on a chest X-ray may suggest aortic dissection?
A widened mediastinum.
What are the risks associated with Stanford Type A dissections?
Risk for myocardial infarction, stroke, aortic regurgitation, cardiac tamponade, Horner’s syndrome, and vocal cord paralysis.
What are the risks associated with Stanford Type B dissections?
Risk for limb ischemia, renal ischemia, and mesenteric ischemia.
What is the test of choice for diagnosing aortic dissection in hemodynamically stable patients?
CT angiography (CTA).
What is the test of choice for diagnosing aortic dissection in hemodynamically unstable or CKD patients?
Transesophageal echocardiography (TEE).
What is the management approach for Stanford Type A dissections?
Surgical emergency.
