Anxiety disorders Flashcards

1
Q

anxiety

A

diffuse unpleasant vague sense of apprehension in anticipation of a future threat

something that could go wrong

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2
Q

fear

A

emotional response to a real or perceived imminent threat

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3
Q

differences between fear & anxiety

A
  • fear associated with surges in automatic arousal - fight or flight
  • Anxiety associated with muscle tension & vigilance in prep for future danger
  • Anxiety also characterised by avoidance behs
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4
Q

anxiety disorders

A
  • Specific phobia
  • Social anxiety disorder (social phobia)
  • Panic disorder (sometimes + agoraphobia)
  • Generalised anxiety disorder
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5
Q

core symptoms of anxiety disorders

A
  • physiology - fear
  • escape - how you would get rid of the fear
  • avoidance - avoid coming into contact with the fear provoking stim itself
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6
Q

genetics of anxiety

A
  • Whether genetic or environmental factors influence on human psychiatric disorders is of course a question of relevance
  • First-degree relatives are most likely to have the same anxiety disorder as the proband (Fyer et al 1995), but first-degree relatives are also at increased risk for other anxiety disorders
  • But, as always, the environment is critical.
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7
Q

gene-environment interactions (PTSD)

A
  • can have the genes but need an environmental stressor
  • With a susceptible brain there would be a smaller hippocampus - one of the conditions to increase bio susceptibility
  • Without heritable component may experience the event but not develop PTSD
  • With susceptible brain the experience will lead to a high risk of PTSD
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8
Q

gene-environment interactions (animal model)

A
  • Cross-fostering study: can take pups from high-licking bio mother to low-licking postnatal mother
  • Having at least one factor of high-licking beh (prenatal or postnatal) will result in low anxiety
  • Both bio & experience
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9
Q

gene-environment interaction

anxiety

A
  • Anxiety disorders involve a shared core with illness-specific signs and cognitions
  • Characterized by fear (short term of long term) and avoidance behaviours
  • Although genes account for variance in anxiety disorders, genes alone cannot explain it all, and the environment is critical.
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10
Q

classical conditioning in anxiety

A
  • Phenomena: phobia, exposure therapy, desensitization
  • induce in the lab - learn beh
  • Pairing of neutral event with foot shock/mild electric shock
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11
Q

avoidance learning

compartment example

A
  • 2 compartments - door in between
  • Noise = shock on one side
  • They learn to move to other component to avoid the shock
  • Threat conditioning –> avoidance learning –> avoidance performance
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12
Q

avoidance learning

screen example

A
  • start with a black screen
  • Don’t show designated response = shock
  • Can avoid aversive event (shock) through avoidance response - teach them how to avoid the shock
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13
Q

mowrer 2-factor theory

A
  • classical & operant conditioning
  • Fear to a stimulus through classical conditioning
  • Instrumental conditioning (avoidance learning): animals escape/postpone aversive
  • avoidance critical in maintenance of anxiety: -ve reinforcement
  • Fear is main driver of avoidance

Also cognitive (Seligman & Johnston, 1973)

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14
Q

fear & avoidance

A
  • 2 factor theory: unidirectional, fear –> avoidance
  • Treatment has been oriented to attenuate fear
  • Newer conceptualizations (last decade) emphasize the bidirectional relationship between fear and avoidance, unlike Mowrer’s theory
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15
Q

amygdala in fear & anxiety

A
  • Amygdala is involved in the fear reaction to a threat (snake)
  • Prediction that amygdala is overactive in anxiety states
  • However, the current focus is on a “fear network” rather than a single structure (LeDoux, 2015)
  • Amygdala results in bodily reactions to fear
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16
Q

amygdala hub in the wheel of fear

A
  • Diff regions which project to amygdala
  • Amygdala then projects to other regions for beh response
  • Seen across species: in humans amygdala is much smaller
  • Medial prefrontal cortex inhibits activity in amygdala hence extinction in learning
17
Q

amygdala activation by fearful faces & conditioned fear

A
  • Human studies
  • Classical fear conditioning in fMRI scanner
  • Wired to process certain info in a specific way
18
Q

emotional processing can be implicit

amygdala & fear

A
  • responses to fearful eyes are subliminal
  • Train with short stim
  • Cannot verbalise that you have seen - don’t know that you have seen it
  • Fear & happy eyes produce diff responses in amygdala
19
Q

amygdala & PFC in extinction

A
  • vmPFC signal increased as extinction progresses
  • signal in amygdala reduces over extinction
  • If you start to produce CS without the shock the freezing response decreases
  • Start to learn it doesn’t produce aversive stim
  • Brain activity in medial prefrontal cortex:
  • whilst extinction is happening more activity,
  • learning to inhibit freezing response - inhibits activity in the amygdala,
  • more extinction correlates with more activity
20
Q

amygdala activation during avoidance

A
  • Avoidance tends to be elicited by fear
  • Learning about rewards - experiment
  • didn’t use shocks - punishment through taking money
  • Reward vs avoidance learning
21
Q

amygdala activation in high trait anxiety

A
  • Individuals high in trait anxiety showed increased amygdala responsivity to phasic fear cues
  • Amygdala: activity correlates to levels of anxiety - don’t know what comes first
22
Q

vmPFC activation in high trait anxiety

A
  • Individuals high in trait anxiety showed impoverished pre-extinction ventral prefrontal cortical (vPFC) activity
  • Inverse relationship: negative correlation
  • More anxiety = less activity
23
Q

amygdala activation in phobias

A

Spider phobics show greater amygdala responses compared to controls, to phobic pictures as well as fear and disgust pictures.

24
Q

amygdala activation in PTSD

A
  • PTSD group showed greater recruitment right amygdala + hippocampus during the construction of emotionally intense negative autobiographical memories
  • Control group showed greater recruitment during construction of emotionally intense positive memories.
  • Remember intense -ve autobiographical mem & look at brain activity when constructing these
  • PTSD diagnosis = much more activity when constructing -ve
  • Control = more activity when constructing +ve mem
25
Q

vmPFC activation in PTSD

A
  • PTSD group showed greater recruitment of the ventral medial PFC for negatively intense autobiographical memories
  • Control group showed greater recruitment for positively intense memories
26
Q

generalised anxiety disorder

meta-analysis

A
  • structural and functional differences in GAD and controls
  • Amygdala hyperactivation and PFC hypoactivation
27
Q

OCD and reversal learning

A
  • Fear conditioning reversal learning - learn one stim safe one isn’t (shock), this is then reversed
  • OCD patients learned the discrimination early on.
  • But failed to discriminate following reversal (early or late)
  • OCD patients have deficit in reversal learning
  • Overactivation of PFC in OCD patients to safety signal (face not paired with shock)
  • Failure to reverse contingencies
  • Higher PFC activation predicted generalization during reversal
28
Q

3 main classes of anxiolytic drugs

A
  • antidepressants
  • benzodiazepine
  • buspirone
29
Q

benzodiazepines

A
  • e.g. librium or chlordiazepoxide; valium or diazepam
  • Anxiolytic use mainly in Generalized Anxiety Disorder and acute stress reactions
  • Also used as anti-convulsants (e.g. in alcohol withdrawal) and as hypnotics
  • Low toxicity: high safety ratio, unlike the barbiturates which they replaced
30
Q

benzodiazepine disadvantages

A
  • the induction of dependence and associated withdrawal syndrome (e.g. insomnia, anxiety, loss of appetite)
  • impairment of cognitive performance e.g. anterograde amnesia
31
Q

serotonin pathways in human brain

A
  • the 5-HT1A autoreceptor resides on the soma and dendrites of serotonin neurons in the raphe nuclei
  • Where its activation hyperpolarizes and reduces the firing rate of these cells
  • thereby serotonin extracellular levels in its projection areas
  • 5-HT1A receptor agonists may act here to reduce 5-HT neuron activity (e.g. in the Amygdala)
32
Q

amygdala responses to fearful faces linked to serotonin system

A
  • healthy volunteers with the short allele of the serotonin transporter (5HTTLPR) polymorphism show increased amygdala responses to fearful faces
  • in patients with depression, the amygdala response to fearful faces is reduced by 8 week SSRI treatment (compared to placebo)
33
Q

psychological treatments

A
  • CBT & exposure therapy
  • enhancing exposure therapy with drugs
  • amnesia following memory retrieval
34
Q

CBT & exposure therapy

A
  • Exposure based therapies and CBT are the first line of treatment in the UK (and worldwide) for anxiety disorders
  • work on the assumption that some fears are learned and therefore presentation of stimuli associated with a feared outcome will extinguish the fear and anxiety
35
Q

enhancing exposure therapy with drugs

A
  • DCS: partial agonist for the Glutamate NMDA receptor
  • Walker et al., (2002) tested the effect of DCS on fear extinction in rodents
  • Dose-dependent effect in facilitation of extinction
36
Q

amnesia following memory retrieval

experimental treatment anxiety

A
  • protein synthesis inhibition in the amygdala blocks reconsolidation of fear.
  • So too does systemic or Intra-amygdala propranolol (Beta blocker; NA-R antagonist)
  • In PTSD: blockade of these soon after the traumatic event (consolidation) decreases the likelihood of developing PTSD in the following 3 months.
37
Q

safety behaviour fading

A
  • technique that is being trialled to diminish safety behaviours
  • Try to diminish avoidance behs