Antonova⭐

Question 1

Year

Answer 1

2011

Question 2

Aim

Answer 2

Test the role of acetylcholine in the encoding of cognitive maps in humans.

Question 3

Sample

Answer 3

20 male adults, mean age 28

Question 4

Procedure

Answer 4

70-90 minutes before task, injected with either scopolamine (antagonist) or placebo.

Put in fMRI to play ‘Arena Task’ (measuring spatial memory)
- learn to locate object in area
- screen went blank 30 secs, told to rehearse navigation
- relocate object from new start point using spatial memory

brain activity measure, 6 trials

3-4 weeks later
Redid task but opposite treatment. (counterbalanced repeated measures)

Question 5

Results and conclusion

Answer 5

Scopolamine showed significant reduction in activation of hippocampus. Shows that acetylcholine plays a key role in the encoding of spatial memory.