Antivirals

Question 1

Enfuvurtide?

Answer 1

HIV: membrane fusion

Question 2

Amantadine and rimantadine?

Answer 2

Influenza: blocks M2 channel; prevents uncoating upon entry

Question 3

What do nucleoside analogs prevent a virus from doing?

Answer 3

Replicating genome

Question 4

Acyclovir

Answer 4

Herpesvirus: genome replication by blocking TK

Question 5

What types of viruses does RIbavirin affect?

Answer 5

RNA viruses: inhibits polymerases and lowers GTP

Question 6

Which antiviral blocks the cleavage of genes in HIV?

Answer 6

Ritonavir

Question 7

Which antivirals block attachment?

Answer 7

1. Enfuvirtide: HIV

Question 8

What do cells have that natural fight viruses?

Answer 8

Interferons (more effective against RNA)

Question 9

What antivirals block the uncoating of the virus genome in the cell?

Answer 9

1. Amantadine (flu)

Question 10

What antivirals block late protein synthesis and processing?

Answer 10

Protease inhibitors (HIV)

Question 11

What antiviral is a neuraminidase inhibitor?

Answer 11

Tamiflu

Question 12

Which antivirals block nucleic acid synthesis?

Answer 12

1. NRTIs and NNRTIs (HIV)
2. Acyclovir (HSV)
3. Entecavir (HBV)

Question 13

What is passive immunization?

Answer 13

Administering antibodies produced in someone else’s body. No virus given.

Question 14

Which type of vaccine does not induce cell mediated immunity?

Answer 14

Killed