antivirals

Question 1

Acyclovir

Answer 1

Nucleoside analogue.

Question 2

Acyclovir resistance

Answer 2

mutation of the thymidine kinase gene. Cross resistance w/ other antivirals with similar mechanism

Question 3

Acyclovir adverse effects

Answer 3

nausea, headache, diarrhea. Reversible crystalline nephrotoxicity. Maintain hydration

Question 4

Valacyclovir

Answer 4

Prodrug of acyclovir. 3-5x greater oral bioavailability than acyclovir

Question 5

Foscarnet

Answer 5

Does not require phosphorylation step as in acyclovir.

Question 6

Ganciclovir

Answer 6

requires viral kinase to be activated

Question 7

Resistance go ganciclovir

Answer 7

Mutation of the UL97 gene is most common

Question 8

What is prodrug of ganciclovir

Answer 8

Valganciclovir

Question 9

What is most common complication of influenza

Answer 9

pneumonia, either primary viral or secondary bacterial pneumonia

Question 10

mech of action of oseltamivir

Answer 10

Binds active site of neuraminidase to inhibit its function. Inhibits spread of progeny virions thru the respiratory tract

Question 11

What does zanamivir treat and how is it administered

Answer 11

Influenza antiviral administered via inhalation

Question 12

What does peramivir treat and how is it administered

Answer 12

influenza, via IV

Question 13

Amantadine and Rimantadine are effective against what strain of influenza

Answer 13

Influenza A M2 prtn

Question 14

Which drugs act on HVC NS3/4A

Answer 14

The protease inhibitors paritaprevir and simprevir

Question 15

Mutation leading to resistance of paritaprevir

Answer 15

Specific NS3 gene substitutions can render the virus resistant

Question 16

What is ledipasvir

Answer 16

Drug used to treat Hep C. A HCV NS5A inhibitor