Antipsychotic Flashcards
Define psychosis
Denotes a variety of mental disorders with multiple causes and manifestations
-systemica nd psychiatric diseases
-Toxic manifestations of chemical agents
Associated with delusions and hallucinations
Schizophrenia
Severe type of psychosis
Positive symptoms of schizophrenia
delusions, hallucinations, agitation, paranoia, aberrant thinking, intrusion of thoughts
Negative symptoms of schizophrenia
emotional apathy, socially withdrawn, inattentiveness
Dopamine hypothesis of schizophrenia
alterations of dopamine levels. Hyperactivity of the mesolimbic/mesocortical DA system. Excessive limbic DA activity leads to psychosis.
Action of schizophrenic drugs
Block D2 receptors (Dopamine hyposthesis)
Blockade of 5HT2A receptor (serotonin hypothesis)
Benefit of atypical vs typical antipsychotics
Atypical have fewer extrapyrimidal side effects.
antipsychotic agents-therapeutic indications
schizophrenia, psychotic behavior, severe mania, antiemetic
Most efficacious treatment?
Drugs plus social therapy
Dopamine receptor antagonists act on what Dopamine receptor
post synaptic D2
Atypical agents inhibit what receptors typically
Antagonists of 5HT2A receptors and D2 receptors
Which two drugs associated least strongly with EPS
Clozapine and quetiapine
Reasons pts stop antipsychotic therapy
lack of efficacy lack of disease insight weight gain EPS Sedation Sexual side effects
