anti fungal Flashcards
1
Q
5 drugs targeting ergosterol synthesis
A
fluconazole, itraconazole, voriconazole, naftifine, terbinafine
2
Q
Drug targeting membrane function
A
amphotericin B
3
Q
Cell wall synthesis
A
caspofungin
4
Q
How does amphotericin B work
A
Binds ergosterol in fungal cell membrane, forms Amp B containing pores, altering membrane permeability
5
Q
what drug has highest therapeutic index of all azoles
A
Fluconazole
6
Q
What is agent of choice for systemic candidiasis, also cryptococcosis, coccidiomycosis
A
fluconazole
7
Q
How do echinicandins work
A
inhibit fungal cell wall synthesis. Only work on fungi with lots of B glucan in cell wall
