Antiviral

Question 1

once activated, it is a competitive inhibitor of HSV DNA pol

Answer 1

acyclovir and valacyclovir

Question 2

Therapeutic indications for IV administration of acyclovir

Answer 2

1) severe or disseminated HSV mucocutaneous disease
2) neonatal HSV
3) HSV encephalitis
4) varicella zoster disease in immunocompromised

Question 3

Therapeutic indications for oral administration of acyclovir

Answer 3

primary or recurrent infections of HSV

Question 4

Therapeutic indications for valacyclovir

Answer 4

primary and recurrent genital herpes, varicella, zoster, and orolabial herpes

Question 5

• Analogue of pyrophosphate
• Inhibits viral DNA pol (does not require activation)
• blocks release of pyrophosphate and catalytic cycle

Answer 5

Foscarnet

Question 6

Route of administration for foscarnet

Answer 6

IV only

Question 7

Therapeutic indications for foscarnet

Answer 7

1) 2nd line therapy for HSV and varicella that are resistant to acyclovir
2) CMV infections: retinitis, colitis, esophagitis

Question 8

• guanosine analogue
• activated by CMV UL97 kinase
• competitive inhibitor of viral DNA pol
• chain terminator when incorporated into newly synthesized viral DNA

Answer 8

Ganciclovir

Question 9

Route of administration for ganciclovir

Answer 9

IV
oral
intraocular

Question 10

Therapeutic indications for IV administration of ganciclovir

Answer 10

1) delaying progression of CMV retinitis in AIDs patients

2) CMV infections: pneumonitis, colitis, esophagitis

Question 11

IV administration of gangciclovir followed by oral reduces risk of…

Answer 11

CMV in transplant recipients

Question 12

Intraocular injection of what drug is for CMV retinitis

Answer 12

ganciclovir