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Pharm II > Antiulcer meds > Flashcards

Antiulcer meds Flashcards

1
Q

a broad term for an ulcer or erosion that occurs in the esophagus, stomach, and duodenum

A

peptic ulcer

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2
Q

stomach pH of what

A

2 to 5

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3
Q

a thick viscous mucous material that provides a barrier between the mucosal lining and acidic gastric secretions

A

gastric mucosal barrier

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4
Q

occurs from reflux of acid

A

esophageal ulcer

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5
Q

occurs from breakdown of the GMB

A

gastric ulcer

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6
Q

caused by hypersecretion of acid from the stomach

A

duodenal ulcer

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7
Q

classic symptom of peptic ulcer

A

gnawing, aching pain

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8
Q

pain from gastric ulcer

A

30 min to 1.5 hours after eating

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9
Q

pain from duodenal ulcer

A

2 to 3 hours after eating

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10
Q

how long does ulcer healing take

A

1 to 2 months

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11
Q

predisposing factors for PUD

A
  1. mechanical disturbances
  2. genetic influences
  3. environmental influences
  4. H pylori
  5. drugs
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12
Q

usually follows a critical situation such as extensive trauma, such as burns, or major surgery

A

stress ulcer

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13
Q

gram-negative bacillus that is linked with development of peptic ulcer

A

H pylori

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14
Q

how to diagnose H pylori

A

endoscopy and biopsy, urea breath test, blood test

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15
Q

what therapy for H pylori

A

MOC

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16
Q

for quad therapy use an H2 blocker for ____ weeks

A

6

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17
Q

inflammation of the esophagus caused by a reflux of gastric acid content

smoking accelerates the disease process

A

GERD

18
Q

treatment for GERD

A

H2 blockers and PPI

19
Q

relieves GERD symptoms better than an H2 blocker

A

PPI

20
Q

antiulcer drugs

A

tranquilizers
anticholinergics
antacids
H2 blockers
PPI
pepsin inhibitor (sucralfate)
prostaglandin E1 analogue (misoprostol)

21
Q

minimal effect in preventing and treating ulcers, but they reduce vagal stimulation and decrease anxiety

adverse effects: edema, ataxia, confusion, EPS, and agranulocytosis

A

tranquilizers

22
Q

relieve pain by decreasing GI motility and secretion, inhibit acetylcholine and block histamine and HCl; delay gastric emptying time (30min to 1hr before meals)

A

anticholinergic (propantheline bromide)

23
Q

promote ulcer healing by neutralizing HCl and reducing pepsin activity

A

antacids

24
Q

systemically absorbed antacid causing hypernatremia and water retention; metabolic alkalosis and acid rebound

A

sodium bicarb

25
Q

most effective at neutralizing acid can cause acid rebound; hypercalcemia and burnett syndrome

A

calcium carbonate

26
Q

nonsystemic antacids composed of alkaline salts

A

aluminum hydroxide and magnesium hydroxide

27
Q

antacid that can cause diarrhea

A

mag

28
Q

antacids that can cause constipation

A

aluminum and calcium

29
Q

a combo of __ and __ neutralizes gastric acid without causing severe diarrhea or constipation

A

mag and aluminum

30
Q

antigas agents is found in many antacids

A

simethicone

31
Q

dosing interval for antacids

A

1 to 3 hours after meals and at bedtime with at least 2oz of water

should not be administered with other oral meds

32
Q

block H2 receptors of the parietal cells in the stomach reducing gastric acid secretions

promote healing by eliminating the cause

A

H2 blockers

33
Q

examples of H2 blockers

A

cimetidine, famotidine, nizatidine
(-tidine)

34
Q

interactions of cimetidine

A

enhances effects of anticoags, theophylline, caffeine, phenytoin, diazepam, propranolol, phenobarbital, and calcium channel blockers

increase BUN, serum creatinine, serum ALP

MONITOR RENAL LABS and GASTRIC pH

35
Q

cimetidine side effects

A

HA, dizziness, diarrhea, drowsiness, agitation, gynecomastia, and ED

36
Q

suppress gastric acid secretion by inhibiting the hydrogen/potassium ATPase enzyme system located in the gastric parietal cells

block the final step of acid production

A

PPI

37
Q

side effects of PPIs

A

HA, dizziness, diarrhea, constipation, abdominal pain

-prazole

38
Q

which PPI through IV

A

pantoprazole

push slowly 2-5min and dilute

39
Q

when to give PPI and what to watch

A

before meals and LFTs monitored

40
Q

pepsin inhibitors or mucosal protective drug

A

sucralfate

1g, qid 30min before meals and HS

41
Q

prostaglandin analogue

suppress gastric acid secretion and increase cytoprotective mucus in the GI tract

longterm NSAIDs

contraindicated in pregnant women

A

misoprostol

42
Q

misoprostol side effects

A

HA, abdominal pain, nausea, vomiting, flatulence, diarrhea, and constipation

Pharm II (16 decks)

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