Antiulcer meds

Question 1

a broad term for an ulcer or erosion that occurs in the esophagus, stomach, and duodenum

Answer 1

peptic ulcer

Question 2

stomach pH of what

Answer 2

2 to 5

Question 3

a thick viscous mucous material that provides a barrier between the mucosal lining and acidic gastric secretions

Answer 3

gastric mucosal barrier

Question 4

occurs from reflux of acid

Answer 4

esophageal ulcer

Question 5

occurs from breakdown of the GMB

Answer 5

gastric ulcer

Question 6

caused by hypersecretion of acid from the stomach

Answer 6

duodenal ulcer

Question 7

classic symptom of peptic ulcer

Answer 7

gnawing, aching pain

Question 8

pain from gastric ulcer

Answer 8

30 min to 1.5 hours after eating

Question 9

pain from duodenal ulcer

Answer 9

2 to 3 hours after eating

Question 10

how long does ulcer healing take

Answer 10

1 to 2 months

Question 11

predisposing factors for PUD

Answer 11

1. mechanical disturbances
2. genetic influences
3. environmental influences
4. H pylori
5. drugs

Question 12

usually follows a critical situation such as extensive trauma, such as burns, or major surgery

Answer 12

stress ulcer

Question 13

gram-negative bacillus that is linked with development of peptic ulcer

Answer 13

H pylori

Question 14

how to diagnose H pylori

Answer 14

endoscopy and biopsy, urea breath test, blood test

Question 15

what therapy for H pylori

Answer 15

MOC

Question 16

for quad therapy use an H2 blocker for ____ weeks

Answer 16

6

Question 17

inflammation of the esophagus caused by a reflux of gastric acid content

smoking accelerates the disease process

Answer 17

GERD

Question 18

treatment for GERD

Answer 18

H2 blockers and PPI

Question 19

relieves GERD symptoms better than an H2 blocker

Answer 19

PPI

Question 20

antiulcer drugs

Answer 20

tranquilizers
anticholinergics
antacids
H2 blockers
PPI
pepsin inhibitor (sucralfate)
prostaglandin E1 analogue (misoprostol)

Question 21

minimal effect in preventing and treating ulcers, but they reduce vagal stimulation and decrease anxiety

adverse effects: edema, ataxia, confusion, EPS, and agranulocytosis

Answer 21

tranquilizers

Question 22

relieve pain by decreasing GI motility and secretion, inhibit acetylcholine and block histamine and HCl; delay gastric emptying time (30min to 1hr before meals)

Answer 22

anticholinergic (propantheline bromide)

Question 23

promote ulcer healing by neutralizing HCl and reducing pepsin activity

Answer 23

antacids

Question 24

systemically absorbed antacid causing hypernatremia and water retention; metabolic alkalosis and acid rebound

Answer 24

sodium bicarb

Question 25

most effective at neutralizing acid can cause acid rebound; hypercalcemia and burnett syndrome

Answer 25

calcium carbonate

Question 26

nonsystemic antacids composed of alkaline salts

Answer 26

aluminum hydroxide and magnesium hydroxide

Question 27

antacid that can cause diarrhea

Answer 27

mag

Question 28

antacids that can cause constipation

Answer 28

aluminum and calcium

Question 29

a combo of __ and __ neutralizes gastric acid without causing severe diarrhea or constipation

Answer 29

mag and aluminum

Question 30

antigas agents is found in many antacids

Answer 30

simethicone

Question 31

dosing interval for antacids

Answer 31

1 to 3 hours after meals and at bedtime with at least 2oz of water should not be administered with other oral meds

Question 32

block H2 receptors of the parietal cells in the stomach reducing gastric acid secretions promote healing by eliminating the cause

Answer 32

H2 blockers

Question 33

examples of H2 blockers

Answer 33

cimetidine, famotidine, nizatidine (-tidine)

Question 34

interactions of cimetidine

Answer 34

enhances effects of anticoags, theophylline, caffeine, phenytoin, diazepam, propranolol, phenobarbital, and calcium channel blockers increase BUN, serum creatinine, serum ALP MONITOR RENAL LABS and GASTRIC pH

Question 35

cimetidine side effects

Answer 35

HA, dizziness, diarrhea, drowsiness, agitation, gynecomastia, and ED

Question 36

suppress gastric acid secretion by inhibiting the hydrogen/potassium ATPase enzyme system located in the gastric parietal cells block the final step of acid production

Answer 36

PPI

Question 37

side effects of PPIs

Answer 37

HA, dizziness, diarrhea, constipation, abdominal pain -prazole

Question 38

which PPI through IV

Answer 38

pantoprazole push slowly 2-5min and dilute

Question 39

when to give PPI and what to watch

Answer 39

before meals and LFTs monitored

Question 40

pepsin inhibitors or mucosal protective drug

Answer 40

sucralfate 1g, qid 30min before meals and HS

Question 41

prostaglandin analogue suppress gastric acid secretion and increase cytoprotective mucus in the GI tract longterm NSAIDs contraindicated in pregnant women

Answer 41

misoprostol

Question 42

misoprostol side effects

Answer 42

HA, abdominal pain, nausea, vomiting, flatulence, diarrhea, and constipation