Antitubulerculars

Question 1

Antituberculars

Answer 1

MOA: inhibit protein synthesis or inhibit cell wall synthesis

Indications: treatment of TB infections

Contraindications: renal and liver dysfunction

Adverse Effects: pyridoxine (VIT. B6) DEFICIENCY and liver toxicity

Interactions: antacids, seizure medications, anticoagulants

Nursing Considerations:

- tests on liver and kidneys before giving meds
- no alcohol
- watch for bruising 
- must take full course of TB
- pts feel sick when taking this drug

Question 2

Key Drugs: Antituberculars

Answer 2

isoniazid- 
Most widely used antitubercular drug
Given as single drug for prophylaxis or in combo for treatment
Inhibits cell wall synthesis 
“SLOW ACETYLATORS”