Antifungals Flashcards
1
Q
Antifungals
A
MOA: varies with each drug
Indications: specific to each antifungal
Contraindications: liver failure, kidney failure
Adverse Effects: most commonly occur with amphotericin B treatment
Interactions: many drugs d/t metabolism by specific liver enzymes
Nursing Considerations:
- liver and kidney labs - watch for IV adverse effects (can pretreat with antipyretics and antiemetics to reduce these AEs)
2
Q
Key Drugs: Antifungals
A
amphotericin B-
Drug of choice for severe systemic fungal infections
Severe adverse effects - cardiac arrhythmias and nephrotoxicity
Infusion related effects- fever, tachycardia, N/V, headache, etc. (these will happen no matter what, but we can PRETREAT to decrease)
AKA “Amphoterrible”
fluconazole-
GOOD COVERAGE against many fungal infections
Better adverse effect profile than Ampotericin B
Oral and injectable forms
