Antianginal Drugs

Question 1

Broad Categories of Antianginal Drugs

Answer 1

Angina happens when blood supply to heart is reduced and the heart freaks out!

• Beta Blockers (decrease stimulation to heart): metoprolol, carvedilol, labetalol
• Calcium Channel Blockers (slow response of muscle contraction of heart): Diltiazem, Amlodipine
• Nitrates/Nitrites (dilate/relax blood vessels to improve blood flow and O2 Sat in heart): Isosorbide, Dinitrite, Niroglycerine

Question 2

Beta Blockers

Answer 2

Key Drugs: METOPROLOL, CARVADILOL, LABETALOL

• Mechanism of Action and Adverse Effects
  Selective v. Non-selective-Slow Heart rate
• Indications
  Angina, MI, Hypertension, dysrhythmias
• Contraindications
  Systolic Heart Failure, Conduction disturbances, bronchial asthma
• Adverse Effects
  Bradycardia, hypotension, dizziness, blood glucose changes, wheezing, mask hypoglycemia
• Interactions Table23-3
  Additive-diuretics, Ca Channel Blockers

Question 3

Calcium Channel Blockers

Answer 3

Key Drugs: DILTIAZEM, AMLODIPINE

***CHECK apical pulse before giving, if

Question 4

Antianginal Nitrates

Answer 4

Key Drugs: ISOSORBIDE, DINITRITE, NITROGLYCERINE

• Mechanism of Action and Drug Effect
  Relaxation of Smooth muscle-vasodilation
• Indications
  Vasospastic angina, angina
• Contraindications
  Anemia, closed angle glaucoma, hypotension, head injury
• Adverse effects
  Headache, tachycardia, postural hypotension
• Interactions
  Additive hypotensive effects (Alcohol, beta blockers, ca channel blockers)