Antituberculosis Drugs Flashcards
How is the management of TB divided?
Into two phases; the initial phase and the continuous phase.
Describe the initial phase of TB management.
Designed to rapidly reduce the population of M. tuberculosis and minimise bacterial resistance. Utilises four drugs and lasts two months.
Describe the continuous phase of TB management.
Starts once the initial phase ends, consisting of two drugs and lasting four months.
Which drugs are included in the initial phase of TB management?
Isoniazid, rifampicin, pyrazinamide, ethambutol.
What key counselling point should be remembered when starting patients on rifampicin?
Colours all body secretions deep orange.
What is the dose of isoniazid used to treat TB?
300mg OD.
What is the dose of rifampicin used to treat TB in a patient under 50kg?
450mg OD.
What is the dose of rifampicin used to treat TB in a patient over 50kg?
600mg OD.
What is the dose of pyrazinamide used to treat TB in a patient under 50kg?
1.5g OD.
What is the dose of pyrazinamide used to treat TB in a patient over 50kg?
2g OD.
What is the dose of ethambutol used to treat TB?
15mg/kg.
What are the side effects of isoniazid?
Liver toxicity, peripheral neuropathy.
What are the side effects of rifampicin?
Liver toxicity, orange-red discolouration of bodily secretions.
What are the side effects of pyrazinamide?
Liver toxicity.
What are the side effects of ethambutol?
Ocular toxicity (visual disturbances).
