antipsychotics

Question 1

1st and 2nd line

Answer 1

1. atypical antipsychotics

2. typical antipsychotics

Question 2

Atypical antipsychotics egs

Answer 2

Olanzapine, risperidone, quetiapine, clozapine, amisulpride, aripiprazole

Question 3

side effects of atypical antipsychotics

Answer 3

metabolic syndrome, weight gain
elderly- increase risk of stroke (esp olanzapine and risperidone), increased risk of VTE
decreased seizure threshold

Question 4

clozapine

Answer 4

significant risk of agranulocytosis- FBC monitoring is essential during treatment

Question 5

typical antipsychotics

Answer 5

clorpromazine, thioridazine, haloperidol, zuclopentixol, fluphenazine

Question 6

extrapyramidal side effects of typical antipsychotics

Answer 6

Parkinsonism
acute dystonia- eg torticollis, oculogyric crisis
akathisia
tardive dyskinesia

Question 7

other side effects of typical antipsychotics

Answer 7

antimuscarinic- dry mouth, urinary retention, blurred vision, constipation
sedation, weight gain
increased prolactin- galactorhoea, impaired glucose tolerance
neuroleptic malignant syndrome
decreased seizure threshold (greater with atypical)
prolonger QT (esp halloperidol)

Question 8

most popular drug for treatment resistant schizophrenia

Answer 8

clozapine