Antipsychotics Flashcards
Why do antipsychotics cause tiredness?
Histamine (H1) receptor agonism
Why do antipsychotics cause movement disorders?
Excess dopaminergic antagonism
Causes parkinsonisms
Why do antipsychotics cause postural hypotension?
Adrenergic receptor agonism
What is the dangerous SE seen with antipsychotics?
Neuroleptic malignant syndrome
Hypertension, hyperthermia and muscle ridgidity
What is the oldest common phenothiazides?
Chlorpromazine
What is the newest phenothiazide?
Fluphenazine
Which anti-psychotic is used in the frail and elderly?
Pipotiazine, less risk of falls
Name 3 non phenothiazides
Haloperidol
Flupenhixol
Pimozide
Which drugs would be used in the young and fit?
Non phenothiazides, few muscarinic and histamine SE, more movement disorders
Name two atypicals that act on 5HT2A receptors
Clozapine, Risperidone
5HT2A antagonists
Which atypical antipsychotic is used as a sedative?
Quetiapine
What are atypical antipsychotics also used in?
Anaesthetics as a pre-med
Mania, dementia
As an anti emetic
