antiparasites

Question 1

malaria drugs (names)

Answer 1

chloroquine
atovaquone-proguanil
artemisinins
primaquine
quinine
mefloquine

Question 2

chloroquine indication

Answer 2

first line for malaria

good for peds and preg

Question 3

chloroquine ADRs

Answer 3

N/V/D/pn
HA
blurry vision
itching (give benadryl with it)

Question 4

atovaquone-proguanil indication

Answer 4

first line malaria tx in CQ-reist

also tx PJP/PCP pneumo in SMX-DXP

Question 5

atovaquone-proguanil ADRs

Answer 5

N/V/C/pn (if too much N/V/ and cant keep down –> doesnt work)
HA
rash (might ned to stop med)
elevate LFT temporarily

Question 6

atovaquone-proguanil drug interactions

Answer 6

rifampin (increase)

tetracycline (reduce)

Question 7

artemisinins (names)

Answer 7

artemether
artesunate
artemisin combo therapy (ACT)

Question 8

artemisinins indications

Answer 8

first line for WHO

alt option for CDC

Question 9

artemisinins ADRs

Answer 9

neuro effects (in animal studies)
some liver/neutrophil probs
hypersensitivity

Question 10

primaquine MOA

Answer 10

acts in liver stage– the only one

Question 11

primaquine indications

Answer 11

PEP (post exposure prophylaxis) of malaria

Question 12

primaquine CI

Answer 12

G6PD deficiency

preg

Question 13

quinine indication

Answer 13

anti malarial

off-label for leg cramps (but doesnt work…)

Question 14

quinine ADRs

Answer 14

cinchonism (tinnitus, vision prob, HA, dysphoria, N/V, hypotension)
low BGL
low BP
GI
CV: long QT
skin probs
antag myastehnia gravis

Question 15

mefloquine indication

Answer 15

prophylax against CQ-resist p. falcirum

NOT a tx

Question 16

mefloquine ADRs

Answer 16

neuro
cardiac
kids vomit

Question 17

mefloquine CI

Answer 17

preg

kids

Question 18

antileishmaniasis (name)

Answer 18

miltefosine

Question 19

miltefosine indication

Answer 19

leishmaniasis

Question 20

miltefosine ADRs

Answer 20

N/V/D
HA
decrease appetite
dizzy
itching
drowsy
elevate LFT and creatinine

Question 21

miltefosine CI

Answer 21

pregnancy (and don’t get preg 4 mo following completion)

Question 22

anti-ameoba azoles (names)

Answer 22

metronidazole

tinidazole

Question 23

ameoba azole MOA

Answer 23

form free radicals inside microbial cells –> death

Question 24

metronidazole indication

Answer 24

c. diff
trichomoniasis
serious anaerobe infect (and, SSTI, sepsis)
rosacea
h/ pylori
vaginitis

Question 25

metronidazole ADRs

Answer 25

``` CNS (rare) sz, encephalopathy, meningitis liver probs (esp in old ppl) GI: N/V/D/pn HA anorexia dysguesia black hairy tongue leukopenia candidiasis ```

Question 26

metronidazole drug interactions

Answer 26

ETOH/disulfuram rxn warfarin/Li (increase) phenobarbitol (decrease)

Question 27

metronidazole CI

Answer 27

first trimester preg

Question 28

tinidazole indications

Answer 28

trichominiasis bact vaginosis giardasis H. pylori (off label)

Question 29

tinidazole ADRs

Answer 29

metallic taste nausea weak/fatigue

Question 30

paromomycin indication

Answer 30

water-borne parasites 2nd line for lots of things (amebiasos, cryptosporid, giardiasis) adjunct or hepatic coma

Question 31

paromomycin CI

Answer 31

intestinal obstruction

Question 32

paromomycin ADRs

Answer 32

N/D/cramps (with bigger dose)

Question 33

antihelminth (names)

Answer 33

mebendazole albendazole praziquantel

Question 34

mebendazole MOA

Answer 34

prevent gluc uptake | block mucrotubules when trying to grow

Question 35

mebendazole indication

Answer 35

all the worms: hook, pin, round, whip | maybe even tape worm

Question 36

mebendazole ADRs

Answer 36

``` monitor liver fnx and pn, diarhea rash, urticaria angioedema sz, hepatitis (rare) ```

Question 37

mebendazole CI

Answer 37

preg cat C

Question 38

albendazole MOA

Answer 38

inhibit microtubule formation

Question 39

albendazole inidcation

Answer 39

tapeworm | hookworm (off label)

Question 40

albendazole ADRs

Answer 40

``` N/V/D/pn HA vertigo alopecia fever elevate LFT pancytopenia (worse with liver dz, bone marrow suppression) ```

Question 41

albendazole CI

Answer 41

preg cat C

Question 42

albendazole drug interactions

Answer 42

dexmethasone (increase) | praziquantel (increase)

Question 43

praziquantel MOA

Answer 43

affect parasite cell mem perm | cysticidal

Question 44

praziquantel indication

Answer 44

DOC for schistosomiasis (caused from cystericercosis)

Question 45

praziqauntel CI

Answer 45

rifampin

Question 46

praziquantel caution

Answer 46

P450 3A4 metabolite