Antibiotics Flashcards
1
Q
Classes of penicillins
A
Penicillin
aminopenicillin
broad-spectrum IV
antistaphulococcal
2
Q
Penicillins (names)
A
Pen VK (PO) Pen G (IV/IM)
3
Q
Pen VK/G MOA
A
bacteriocidal.
prevent cell-wall synthesis– interrupt cross-link by binding to PCN binding prot (PBP)
4
Q
Pen VK indications
A
strep mild skin infections rheumatic fever prophylaxis (G+ -sterp, staph, enterococcus G- cocci some anaerobic bact (gut/oral))
5
Q
Pen G indicatons
A
syphilis strep rheumatic fever prophylaxis endocarditis 2nd line for lymes
6
Q
Pen G CI
A
with benzathine - IM only
7
Q
Pen G ADRs
A
rash allergic rxn c. diff candidiasis toxic levels --> sz
8
Q
Pen VK ADRs
A
N/V GI upset diarrhea black hairy tongue c. diff anaphylaxis
9
Q
general PCN ADRs
A
rash/anaphylaxis GI probs (N/V/D) c. diff lupus/autoimmune hemolytic anemia sz (esp with renal insufficiency pts)
10
Q
aminopenicillin (names)
A
amoxicillin
amoxicillin+clavulanic acid (augmentin)
ampicillin
ampicillin+sulbactam (unasyn)
11
Q
aminopenicillin MOA
A
penetrate bact cell wall penetration +/- B-lactamase inhibition
12
Q
aminopenicillin indications
A
G+ bact enterococcus anaerobes -combos = better at G-, staph, nisseria meningitidis, -unasyn = good for pseudomonas, n. gonorrhea -augmentin XR = 1st line sinusitits -ampicillin = for shigella ENT infect lower respir tract infect UTI skin infect periodontal dz lyme (1st line)
13
Q
broad-spectrum IV PCNs (names)
A
piperacillin
piperacillin+tazobactam
ticarcillin+clavulanate
14
Q
broad-spectrum IV PCNs indications
A
systemic/serious infect (IV in hops) pseudomonas and other G- septicemia lower respir infect bone/joint dz bad skin infect bad UTI endometritis peritonitis
15
Q
antistaphulococcal (names)
A
naficillin
oxacillin (IV)
cloxacillin (PO)
