Antineoplastic Agents Flashcards
1
Q
- When do cell cycle nonspecific drugs act?
- Types of CCNS
- What drug is most effective against rapidly growing cancers
A
- any phase of the cycle
- alkylating, antitumor antibiotics, hormones
- Cell cycle specific drugs
2
Q
- Types of CCS
- General side effects of chemo
A
- Antimetabolites, mitotic inhibitors
- rapidly growing normal cells, GI tract, mucuous membranes, bone marrow, reproductive system
3
Q
- Hod to Alkylating Drugs work
- What type of cancers
- How does it affect DNA
A
- prevent cell division
- Acute/Chronic Leukemia, lymphoma, multiple myeloma, solid tumors
- cross-linking, abnormal base pairing, DNA stand breaks
4
Q
- Alkylating Agent Types x7
- Name an Alkylsulfonate drug?
- Name a Nitrosoureas drug
A
- Mustard Gad, Ethylenimine, Alkylsulfonates, Hyrazines, Triazines, Nitrosoureas, Metal Salts
- Busulfan
- Carmustine
5
Q
- SE’s of alkylating agents
- What type of drug is Cyclophosphamide?
A
- N/V, hemorhhagi cystitis, alopecia (balding), anemia, leukopenia, thrombocytopenia, bone marrow suppresion, secondary malignancies, sterilitisy
- Alkylating
6
Q
- How is Cyclophsphamide givent?
- What can it cause?
- How does the GI absorb it?
A
- Oral or IV
- blistering, vesicant
- well
7
Q
- Side effect of Cyclophophamide
- How do antimetabolites work?
- Types of cancer its used for?
A
- Hemorrhagic cystitis (blood in urine)
- specific, disrupt metabolic processes and inhibit enzyme synthesis
- leukemia, breast, head/neck, lung, osteosarcoma, nonHodkin’s lymphoma
8
Q
- Antimetabolite classess
A
- folic acid antagonist
- pyrimidine antagonist
- purine antagonist
- adenosien deaminase inhibitor
- ribonucleotide reductase inhibitor
9
Q
- Name an antimetabolite drug
- How is it given?
- What does it do?
A
- Fluorouracil (5-FU), Adrucil
- IV, topical
- blocks DNA and RNA synthesis
10
Q
- How do antitumor antibiotics work?
- Types of antitumor antibiotics?
- Specific or Nonspecific?
A
- inhibit protein and RNA synthesis, bind DNA causing fragmentation
- anthracycline, chromomycin
- Nonspecific
11
Q
- Types of cancers antitumor antibiotics treat?
- Name an antitumor antibiotic?
- What is it?
A
- Leukemia, solid tumors, various others
- Doxorubicin
- prototype drug
12
Q
- SE’s of doxorubicin?
- How is it given
- what is the maximum lifetime dose
A
- cardiotoxic
- IV
- mg/m2
13
Q
- What do plant alkaloids do?
- Specific or nonspecific
- Types of Plant Alkaloids
A
- Block cell division at the Mphase of cell cycle
- specific
- Vinca, antimicrotubule, taxanes, paclitaxel
14
Q
- Hormonal Agents
- What do sex hormones do?
- What do gonatropins do
A
- Steroids, Sex hormones, Antiestrogens, Aromatase inhibitor, Gonadotropin, Antiandrogen
- Slow grown of hormone-dependent tumors
- releasing hormone analogues
15
Q
- Types of targeted therapy drugs? x7
A
- Tyrosine kinase inhibitor
- multikinase inhibitor
- epidermal growth factor/receptor inhibitor
- vascular endothelial growth factor/receptor inhibitor
- proteasome inhibitor
- angiogensis inhibitor
- monoclonal antibodies