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Farmacologie > Antimycotica > Flashcards

Antimycotica Flashcards

Antimycotica

1
Q

Amfotericine

A

Amfotericine
= fungicied, systemische vb aspergillus,
= polyeenn ab. bindt ergosterol

enkel IV
mogelijks nefrotox. / hemolyse

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2
Q

Itraconazole
Fluconazole
Posaconazole

A

azole derivaten (!belangr!) –> triazoles

Azole derivaten =fungistatisch - breedspectrum (systemisch en oppervlakkig )

  • Triazoles = selectiever - beter werkzaam - minder toxisch - langere T 1/2
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3
Q

Ketoconazole
Clotrimazole
Enilconazole

A

Azole derivaten (!belangr!) –> imidazoles

Azole derivaten =- fungistatisch - breedspectrum (systemisch en oppervlakkig)

meer inhibitie stereoidsynthese zoogdier dan triazoles

  • ketoconazole= ook cyp inhibitie zoogdier (nevenw. )
  • Clotrimazole = topicaal / oordruppels
  • Enilconazole = top. huid
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4
Q

Terbinafine

A
  • Terbinafine = Alylamines, inhibitie ergosterolsynthese

oraal/topicaal

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5
Q

Flucytocyne

A

Antimycotica

  • Flucytocyne = stoppen nucl zuur synthese
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6
Q

Nystatine

Natamycine

A

Antimycotica –> topicale antimycotica –> polyeen antibiotica

Polyeen antibiotica = candida, malasseizia

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7
Q

Clotrimazole
Enilconazole
Miconazole

A

Antimycotica –> Topicale antimycotica –> Azole derivaten

Azole derivaten = opp. dermatofyten, candidiasis

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Farmacologie (14 decks)

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