Anti protozoaire middelen Flashcards

Anti protozoaire middelen

1
Q

Metronidazole
Albendazole
Fenbendazole

A

Giardia

Metronidazole = geen FPA

Albendazole + Fenbendazole = benzimedazoles! Inhibitie microtubuli bij helminthen (ook bij giardia in ventrale schijf)
ook voor FPA

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2
Q

Sulfonamide / trimetoprim
Clindamycine
Spiramycine

A

Toxoplasma gondii

  • Clindamycine = lincosamide
  • Spiramycine = macrolide
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3
Q

Paromoycine
Azithromycine
Halofuginone

A

Cryptosporidium

  • Paromoycine, Azithromycine = macroliden
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4
Q

Imidocarb

Doxycycline

A

babesiose

  • Imidocarb = Hond, pa, rund, niet bij kat! - inhibitie DNA replicatie
  • Doxycycline = hond, pa, rund, kat - 2e gen tetracycl.
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5
Q

Sulf/trim
Clindamycine
Ponazuril

A

Anti protozoaire middelen –> neospora canis

  • Ponazuril = anticoccidiose, ook neospora
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6
Q

Nitro imidazoles

A

Trichomonas gallinae, Histomonas meleagridis

Nitro imidazoles :metronidazole

  • Carcinogeen
  • Niet bij FPA
  • Anaerobe activatie intermediaire producten –> oxidatieve stress - lyse
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7
Q

Sulfaquinoxaline
Sulfamethazine
Sulfadimethoxine

A

anti coccidiose middelen –> sulfonamiden

Sulfonamiden =

  • preventief / curatief
  • inhibitie foliumzuursynthese
  • intestinale cocc.
  • +trimetoprim

Tox: onderdrukt microbiota en vit K (evt allergie)

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8
Q

Amprolium

A

anti coccidiose middelen

Amprolium =

  • prev. / cur.
  • vitamine B antagonist
    • sulf/trim
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9
Q

Diclazuril
Toltrazuril
Ponazuril

A

anti coccidiose middelen –> triazine derivaten

  • Diclazuril = prev.
  • Toltrazuril = prev. / cur.
  • Ponazuril = sarcocystis paard
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10
Q

Decoquinaat

A

anti coccidiose middelen

  • Decoquinaat = prev.
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11
Q

Nicarbazine

A

anti coccidiose middelen

  • Nicarbazine = prev.
    niet leghennen
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12
Q

Robenidine

A

anti coccidiose middelen

  • Robenidine = prev. / niet leghennen
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13
Q

Halufuginone

A

anti coccidiose middelen

werking onbekend

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14
Q

Monensin
Narasin
Salinomycine

A

anti coccidiose middelen –> ionofore coccidiostatica –> monovalente ionoforen (Na+)

Ionofore coccidiostatica = ionen complexatie –> intracell –> lyse

  • Monensin = interactie pleuromutulins
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15
Q

Maduramycine

Semduramycine

A

anti coccidiose middelen –> ionofore coccidiostatica –> glycoside monovalente ionoforen

Ionofore coccidiostatica = ionen complexatie –> intracell –> lyse

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16
Q

Lasolocid

A

anti coccidiose middelen –> ionofore coccidiostatica –> divalente ionoforen (Ca+)

Ionofore coccidiostatica = ionen complexatie –> intracell –> lyse

cardiotoxisch voor paard, konijn, kalkoen
Ca influx thv cardiomyocyt, overmatige contractie –>lyse van hartspiercel
kan ook bij andere diersoorten door overdosering