Antimotility drugs

Question 1

Antimotility drugs indication

Answer 1

Diarrhoea normally in IBS

Viral gastroenteritis

Question 2

Antimotility drugs indication

Answer 2

Loperamide, codeine

Question 3

Loperamide MOA

Answer 3

Reducing peristaltic contractions, anal sphincter tone is increased, slower gut transit means more time for water absorption so harder stool.

Question 4

Loperamide adverse effects

Answer 4

Constipation, abdominal cramping, flatulence

Question 5

Ulcerative colitis and antimotility drugs

Answer 5

Not to be used peristalsis may increase risk of perforation

Question 6

Antimotility warnings

Answer 6

Avoid in c diff, not to be used in dysentery (bloody diarrboea) as it signifies infection, its use increases risk of haemolytic uraemic syndrome

Question 7

When to stop antimotility

Answer 7

Constipation, abdominal pain, more than 5 days

Question 8

Antimotility counselling

Answer 8

Only helps symptoms not the underlying cause, stop if constipated/taking more than 5 days/ abdominal pain