Antiemetic phenothiazines Flashcards
1
Q
Main use of antiemetic phenothiazines
A
NV especially due to vertigo and psychotic disorders as typical antipsychotics
2
Q
Phenothiazines examples
A
prochlorperazine, chlorpromazine
3
Q
Phenothiazine antiemetic MOA
A
Arise due to blocking of dopamine and histamine/acetylcholine (but less so) in eceptors in vestibular system and vomiting centre
4
Q
Phenothiazine antiemetic Side effects
A
Drowsiness and postural hypotension, EPS, QT prolongation
5
Q
When to avoid phenothiazine use
A
Liver disease, susceptible to anticholinergic effects like prostatic hypertrophy,
6
Q
Drugs causing QT interval
A
Antipsychotics, amiodarone, ciprofloxacin, macrolides, quinine and SSRIs
7
Q
What is antipsychotic is often used for opioid induced nausea
A
Haloperidol
