Antiemetics dopamine d2 receptor antagonists

Question 1

When should DRA antiemetics be used

Answer 1

Especially in reduced gut motility, nausea due to drugs like opioids or diabetic gastroparesis

Question 2

DRA antiemetic MOA

Answer 2

D2 acts on CTZ the area that senses vomiting causing substances and dopamine is a important neurotransmitter in the gut as it promotes relaxation of the stomach and lower oesophageal sphincter and inhibit gastroduodenal coordination. They have a prokinetic effect, promoting gastric action.

Question 3

DRA antiemetic Side effects

Answer 3

Diarrhoea, EPS in metoclopramide, dodmperidone doent as it does not cross BBB

Question 4

DRA antiemetic problems

Answer 4

Avoid in young adults and children, avoid in those that have GI problems, Dopamine treatment for parkinsons

Question 5

DRA antiemetic examples

Answer 5

metoclopramide, domperidone

Question 6

What DRA could be used in GORD

Answer 6

metoclopramide