Antiemetic - serotonin

Question 1

Serotonin antagonist antiemetic moa

Answer 1

high density of 5-HT3 receptors in the CTZ, so only effective in nausea due to CTZ, visceral stimuli but not motion sickness, chemoreceptor trigger zone is in medulla

Question 2

serotonin antagonist antiemetic side effects

Answer 2

rare but headache, constipation, diarrhoea

Question 3

Serotonin antiemetic warnings/interactions

Answer 3

QT prolongation

Question 4

serotonin antagonist antiemetic examples

Answer 4

ondansetron, granisetron

Question 5

Can serotonin antiemetic be used for morning sickness hyperemesis gravidarum

Answer 5

yes unlicensed though, only if pros outweigh cons