Antimicrobials: Part 5: MOAs of the "other" drugs Flashcards
1
Q
What is the MOA of sulfonamides?
A
Inhibits folate synthesis by blocking dihydropteroate synthase due to how it mimics PABA
2
Q
What is the MOA of sulfones (dapsone)?
A
Same as sulfonamides (inhibits folate synthesis by blocking dihydropteroate synthase due to how it mimics PABA) but with a different structure
3
Q
What is the MOA of trimethoprim?
A
Inhibits dihydrofolate reductase
4
Q
What is the MOA of fluoroquinolone?
A
Inhibits prokaryotic topoisomerase II and IV
5
Q
What is the MOA of metronidazole?
A
Forms toxic free radical metabolites in the bacterial cell that damages DNA
Must be reduced to activate!
