Antimicrobials: Part 1

Question 1

What are the three major groups in which the antibiotic drug classes can be divided?

Answer 1

• Cell Wall and Membrane
• Protein Synthesis
• “Other”

Question 2

What are the subgroups within the “Cell Wall and Membrane” group?

Answer 2

• Peptidoglycan cross-linking
• Peptidoglycan synthesis
• Membrane integrity

Question 3

What are the subgroups within the “Protein Synthesis” group?

Answer 3

• 50S subunit

- 30S subunit

Question 4

What are the subgroups within the “other” group?

Answer 4

• Folic Acid Synthesis and Reduction
• Gyrase
• DNA integrity via free radicals

Question 5

What are all the drug classes within the “peptidoglycan cross-linking” subgroup?

Answer 5

Peptidoglycan cross-linking:

• Penicillinase-sensitive penicillins
• Penicillinase-resistant penicillins
• Antipseudomonals
• Cephalosporins, generations I-V
• Carbapenems
• Monobactams

Question 6

What is the drug class within the “peptidoglycan synthesis” subgroup?

Answer 6

Glycopeptides

Question 7

What are all the drug classes within the “membrane integrity” subgroup?

Answer 7

• Polymyxins

- Daptomycin

Question 8

What are all the drug classes within the “30S” subgroup?

Answer 8

• Aminoglycosides
• Glycylcyclines
• Tetracyclines

Question 9

What are all the drug classes within the “50S” subgroup?

Answer 9

• Macrolides
• Streptogramins
• Chloramphenicol
• Clindamycin
• Linezolid

Question 10

What are all the drug classes within the “Folic Acid Synthesis and Reduction” subgroup?

Answer 10

• Sulfonamides
• Sulfones (Dapsone)
• Trimethoprim

Question 11

What is the drug class within the “Gyrase” subgroup?

Answer 11

Fluoroquinolones

Question 12

What is the drug class within the “DNA integrity via free radicals” subgroup?

Answer 12

Metronidazole