Antimicrobials: Part 10: Clinical uses of drugs that affect protein synthesis

Question 1

What are the clinical uses of aminoglycosides?

Answer 1

• Severe gram - rod infections
• Synergistic with beta-lactams
• Neomycin for bowel surgery

Question 2

What are the clinical uses of tetracyclines?

Answer 2

• Covers many atypicals
• Accumulates intracellularly –> hence it is good for borrelia, mycoplasma, rickettsia, and chlamydia
• Covers most zoonoses
• Treats acne
• Absorption can be affected by minerals and antacids like calcium, magnesium, iron
• Doxy is effective against community-acquired MRSA

Question 3

What are the clinical uses of tigecycline?

Answer 3

• Broad spectrum anaerobic, gram +, and gram - coverage

- Works on MRSA, VRE, or anything that needs deep tissue penetration

Question 4

What are the clinical uses of chloramphenicol?

Answer 4

• Rarely used due to side effects
• Broad coverage of gram positives and negatives and atypicals
• Can treat meningitis and rickettsial diseases
• Can replace doxycycline in pregnant people in the first and second trimester

Question 5

What are the clinical uses of clindamycin?

Answer 5

• Covers some gram positives, but main use is to cover anaerobes
• Covers above the diaphragm
• Aspiration PNA
• Lung abscesses
• Oral infections

Question 6

What are the clinical uses of linezolid?

Answer 6

Treats VRE and MRSA

Question 7

What are the clinical uses of macrolides?

Answer 7

• Good for atypical pneumonia and pneumonia in patient’s with penicillin allergy
• Used for chlamydia and B. pertussis
• Often coadminister with ceftriaxone for gonorrhea