Antimicrobials: Part 11: Clinical uses of the "other" drugs

Question 1

What are the clinical uses of sulfonamides?

Answer 1

• Used with trimethoprim → bactrim
• Covers many positives, negatives, and nocardia but does not cover pseudomonas and bacteroides
• Used for UTIs and pneumocystis pneumonia

Question 2

What are the clinical uses of sulfones (dapsone)?

Answer 2

Used in mycobacterium leprae and P. jirovecii when used with TMP

Question 3

What are the clinical uses of trimethoprim?

Answer 3

• Used with SMX to make bactrim

- Used for UTIs, shigella, salmonella, P. jirovecii, PNA tx and prophylaxis, and toxoplasma prophylaxis

Question 4

What are the clinical uses of fluoroquinolones?

Answer 4

• Very good gram negative coverage
• Most reliable pseudomonas coverage
• Some gram + infections
• Good for otitis externa

Question 5

What are the clinical uses of metronidazole?

Answer 5

Good coverage of anaerobes below the diaphragm:

• Clostridium
• Bacteroides
• Part of H. pylori treatment
• Gardnerella vaginalis
• Trichomonas
• Entamoeba
• Giardia