Antimicrobial Resistance & Zoonoses

Question 1

Fill in the blanks:
Staphylococcus spp.
Genus: ___________ Species:______________
Gram (+ or -) _____ Coagulase (+ or -) ____

Answer 1

Genus: Staphylococcus Species: Staphylococcus aureus
Gram-positive cocci bacterium Coagulase positive

Question 2

• Normal inhabitant of the skin and/or nose of healthy people and some animals
• Opportunistic Pathogen
  - No detrimental risks to ImmunoCOMPETENT host
  - Severe infection or death in ImmunoCOMPROMISED host

Answer 2

Staphylococcus spp.

Question 3

How does S. aureus become an MDR (multidrug resistance) Pathogen?

Question 4

One of the Top Three pathogens that a dog or cat has in their mouth that can produce infections in humans is _____________

Answer 4

Staphylococcus aureus

Question 5

What would be the best antibiotic to treat Staph infections?

Answer 5

Beta-lactams

Question 6

Any S. aureus that acquires the ___________ can expressed an altered penicillin-binding protein

Answer 6

mecA gene

Question 7

__________ cannot be efficiently block by beta-lactams drugs due to low avidity (or attraction)

Answer 7

PBP2a

Question 8

Other Staphylococcus can also carry the mecA gene such as:

Answer 8

• Methicillin-resistant S. pseudintermedius (MRSP)
• Methicillin-resistant S. schleiferi (MRSS) subspecies coagulans

Question 9

In OSU approximately what percentage of the dogs come in to a practice carry MRSA with them?

Answer 9

1%

Question 10

For maximum effectiveness, proper use of alcohol-based hand sanitizers includes:

Answer 10

• Sufficient contact time (20-60 seconds)
• Sufficient volume to make the entire surface area of hands moist
• Application on hands that are visibly clean

Question 11

(T/F) There are bacterial organisms that possess intrinsic resistance to certain antimicrobial drugs despite never being exposed to them. These drugs should not be used to treat diseases caused by these organisms as they will fail and can promote the development of resistance in other flora present in the body.

Answer 11

True

Question 12

(T/F) S. aureus that has acquired the mecA gene are considered superbugs because they are more resistant to disinfectants, survive longer in the environment and produce stronger biofilms

Answer 12

False

Question 13

(T/F) Prevalence of MRSA in veterinary personnel in different veterinary settings and geographical regions varies significantly, but the risk is not zero as they generally have higher colonization rates than the general population where they live

Answer 13

True