Antimicrobial need to knows

Question 1

what can measure total cell counts

Answer 1

Flow cytometry, Turbidimetry and microscopic count

Question 2

beta-lactams

Answer 2

penicillin and cephalosporin

Question 3

beta-lactams target

Answer 3

Tpase- inhibit peptidoglycan

Question 4

b-lactams more effective against

Answer 4

gram positive- bc more peptidoglycan = more damage

Question 5

Aminoglycoside 2 examples

Answer 5

kanamycin and streptomycin

Question 6

aminoglycisodes target

Answer 6

30S subunit- mRNA misreading - proteins synthesis

Question 7

aminoglycosides effect on microorganism is

Answer 7

bactericidal - kill

Question 8

Chloramphenicol (chlor-ram-phen-e-coal) target ____

Answer 8

23S rRNA (50S) - bacteriostatic - inhibit

Question 9

Macrolides example

Answer 9

Erythromycin (E-rith-row-mycin)

Question 10

Macrolides and Tetracyclins both block

Answer 10

protein synthesis

Question 11

Macrolides and Chloramphenicols target the ___S subunit while Tetracycline and Aminoglycosides target the ____S subunit

Answer 11

50 S, 30 S

Question 12

Growth factor analogs main example

Answer 12

Sulfanilamides (Suf-ann-ill-a-mide)

Question 13

sulfanilamides ( growth factor analogs) target

Answer 13

folic acid synthesis

Question 14

Nucleic acid base analogs such as ________ target _______

Answer 14

5-fluorouracil acyclovir targets mRNA synthesis and viral polymerase

Question 15

Quinolones such as _______ target _____

Answer 15

Cyprofloxacin target DNA gyrase

Question 16

Ergosterols synthesis example _______ target______

Answer 16

Nystatin , Fluconazole target ergosterol synthesis

Question 17

Cyprofloxacin is in ____ class

Answer 17

Quinalone

Question 18

Cyprofloxacin inhibits/targets

Answer 18

DNA gyrase - inhibiting cell division = bacteriostatic

Question 19

4 drugs that inhibit protein synthesis

Answer 19

1. chloramphenicol (from chloramphenicol group)
2. Erythromycin ( Macrolides group )
3. Streptomycin & Kanamycin (Aminoglycoside group)
4. Tetracyclins (tetracyclines group )

Question 20

which drug inhibits folic acid synthesis

Answer 20

Sulfanilamides from the Growth factor analog group

Question 21

Ergosterol synthesis group drugs - examples

Answer 21

Nystatin and Fluconazole

Question 22

what is ergosterol

Answer 22

analogous to cholesterol in the membrane of animals- only in fungi and yeast

Question 23

Chloramphenicol targets

Answer 23

23S rRNA- block peptide elongation and protein synthesis

Question 24

Ciprofloxacin targets

Answer 24

DNA gyrase ( part of Quinalone group )

Question 25

Cephalosporin targets

Answer 25

Peptidylglycan ( in Beta-lactam group with penicillin)

Question 26

which 4 groups are soley bacteriostatic?

Answer 26

Chloramphenicol,

Tetracyclines, Macrolides and Growth factor analougs

Question 27

Which 2 are bactericidal ?

Answer 27

Amino glycosides and Quinalones

Question 28

how do beta-lactams interact/kill/inhibit microgranisms?

Answer 28

Bacteriostatic, cidcal and lytic