Antilipidemics And Perioheral Vasodilators

Question 1

Triglycerides

Answer 1

40-150

Question 2

HDL

Answer 2

Above 60

Question 3

LDL

Answer 3

Below 60

Question 4

Nonpharmacoligic ways to cholesterol reduction

Answer 4

Reduced intake of sat. Fats and cholesterol

Exercise

Stop smoking

Question 5

Resin antihyperlipidemics

Answer 5

Lower lipid levels

Question 6

Bile-acid sequestrants

Answer 6

Binds with bikes salts
Cholestyramine(queatran)

A gritty powder, mix with 4-6 ounces of water

Colesevelam HCL(welchol)
LessGI side effects

First choice
Causes rise in triglycerides

Question 7

Finnic acid derivatives

Answer 7

Gemfibrozil(lopid)

Reduces LDL AND VLDL

SE,AR: GI disturbances, hyperglycemia, abnormal liver function,flushed skin

Large doses cause vasodilation resulting in dizziness and hypotension, better tolerated if given with aspirin

Question 8

Statins/Vastatins

HMG COA refuctase inhibitors

Answer 8

Inhibits cholesterol synthesis in the liver, resulting in a decrease of cholesterol concentration

Lowers LDL and raises HDL

Rosivastatin(Crestor)

SE: headache,rash,constipation, diarrhea
AR: liver impairment
NI: monitor liver enzymes and lipid levels

Question 9

Ezemtimibe(zetia)

Answer 9

Add with nystatin for best affect

Inhibits cholesterol absorption in small intestine

Simvastatin+ezetimibe=Vytorin

Question 10

Peripheral artery disease

Answer 10

Characterized by numbness and coolness in extremities, intermittent claudication, and ulcerations(Reynauds disease)

Etiology: arteriosclerosis+hyperlipidemia= atherosclerosis

Question 11

Reynauds disease

Answer 11

Use peripheral dilators: cilostazol(pletal)

NO SMOKING

Question 12

Papavarine(para-time)

Answer 12

Potent vasodilator

Use vasopressor if papavarine infiltrates

Question 13

Cholesterol

Answer 13

150-200