Antihyperlipidemic Drugs

Question 1

• lower serum levels of cholesterol
  and various lipids
• these drugs provide effective
  treatment for hyperlipidemia
  (increased lipid level in the blood).

Answer 1

ANTIHYPERLIPIDEMIC
DRUGS

Question 2

ANTIHYPERLIPIDEMIC DRUGS is also called as?

Answer 2

lipid-lowering agents

Question 3

the most common cause of death among adults (higher in people with hyperlipidemia)

Answer 3

coronary artery disease (CAD)

Question 4

fatty streaks develop into plaques and
injure the lining of blood vessels is called as?

Answer 4

(atheromas)

Question 5

give 3 steroid hormones from

Answer 5

glucocorticoid, mineralocorticoid, adrenocorticoid

Question 6

important source of energy that can be stored all throughout the body

Answer 6

Triglycerides

Question 7

what is the carrier/ protein capsule that carries fats to transport throughout the body?

Answer 7

Lipoproteins

Question 8

3 Types of Lipids

Answer 8

cholesterol, tryglycerides, and phospholipids

Question 9

important in the synthesis of bile acids, steroid hormones, and maintain the integrity of cell membrane

Answer 9

Cholesterol

Question 10

Four Types of Lipoproteins

Answer 10

1. Chylomicrons
2. Very Low-Density Lipoproteins (VLDL)
3. Low-Density Lipoproteins (LDL)
   4.High-Density Lipoproteins (HDL)

Question 11

what type of lipoprotein is considered as good cholesterol?

Answer 11

High-Density Lipoproteins (HDL)

Question 12

what type of lipoprotein is considered as bad cholesterol?

Answer 12

Low-Density Lipoproteins (LDL)

Question 13

Types of Lipoproteins

produced in the GIT from
dietary lipids and deliver energy-rich
triglycerides to the cells throughout the body

Answer 13

Chylomicrons

Question 14

Types of Lipoproteins

produced in the liver and deliver energy-rich
triglycerides to the cells throughout the body

Answer 14

Very Low-Density Lipoproteins (VLDL)

Question 15

Types of Lipoproteins

came from transformed VLDL which deliver this
cholesterol TO THE CELLS (for cell membrane
and steroid hormone synthesis) and half are
taken by the LIVER for bile acid production

Answer 15

Low-Density Lipoproteins (LDL)

Question 16

important in the absorption of
fats (by acting like a dishwashing detergent
that breaks up the grease and fats in the
dishwashing water; bile acids do much the
same thing) and fat-soluble vitamins

Answer 16

bile acids

Question 17

Types of Lipoproteins

• transport excess cholesterol FROM
  CELLS back to the liver

Answer 17

High-Density Lipoproteins (HDL)

Question 18

ANTIHYPERLIPIDEMIC Drug

• blocks the completion of cholesterol synthesis in the body / statins
• PREGNANCY CATEGORY X
• can be used as prophylaxis for first myocardial infarction attack for patients with multiple risk factors for CAD.
• Older adults are more susceptible to drug toxicity because of underlying conditions that would interfere with metabolism and excretion of drug

Answer 18

HMG-CoA Reductase Inhibitors or
“STATINS”

Question 19

ANTIHYPERLIPIDEMIC Drug

• exert their effect in the INTESTINE by binding into bile acids which contain a high level of cholesterol.
• used as the treatment for primary
  hypercholesterolemia (high cholesterol and high LDL) as an adjunct to diet and exercise.
• drug of choice for pregnant women in lowering cholesterol and lipid levels.

Answer 19

Bile Acid Sequestrants

Question 20

ANTIHYPERLIPIDEMIC Drug

• block the absorption of dietary cholesterol
• one of the new class of drugs approved
  (2003) to lower serum cholesterol levels

-Adjunct to diet and exercise as a monotherapy or in combination with HMG-CoA inhibitors or bile acid sequestrants.

Answer 20

Cholesterol Absorption Inhibitors

Question 21

ANTIHYPERLIPIDEMIC Drug

• It inhibits the release of free fatty acids
  from adipose tissue, increases the rate of
  triglyceride removal from plasma, and
  generally reduces LDL and triglyceride
  levels and increases HDL levels.
• It inhibits hormone-sensitive lipase that
  converts triglycerides to free fatty acids

Answer 21

Nicotinic Acid (Vitamin B3 – Niacin)

Question 22

Bile Acid Sequestrants drug used to treat pruritus associated with partial biliary obstruction.

Answer 22

Cholestyramine

Question 23

cole or chole

Answer 23

Bile Acid Sequestrants drug

Question 24

• drug that increases serum levels of uric acid and may predispose patients to the development of gout
• often combined with bile acid
  sequestrants for increased effect.

Answer 24

Nicotinic Acid (Vitamin B3 – Niacin)

Question 25

when is the proper time to give Nicotinic Acid (Vitamin B3 – Niacin)?

Answer 25

at bed time bc synthesis of lipids usually happens at midnight

Question 26

ANTIHYPERLIPIDEMIC Drug

• stimulate the breakdown of lipoproteins
  from the tissues to fatty acids and their
  removal from the plasma.

-They lead to a decrease in lipoprotein
and triglyceride synthesis and secretion.

-absorbed from the GI tract and are metabolized in the liver
and excreted in urine.

Answer 26

Fibrates

Question 27

clue for fibrates drugs?

Answer 27

fib at he middle

Question 28

Cholesterol Absorption
Inhibitors only drug is?

Answer 28

Ezetimibe

Question 29

fat soluble vits

Answer 29

A D E K