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Basic Pharmacology > Antihelminthic Drugs > Flashcards

Antihelminthic Drugs Flashcards

1
Q

Drugs active against nematodes

A 
albendazole
diethylcarbamazine
Ivermectin
Mebendazole
Pyrantel pamoate
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2
Q

Drugs active against trematodes

A

praziquantel
bithionol
metrifonate
oxamniquine

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3
Q

Drugs active against cestodes

A

niclosamide

praziquantel

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4
Q

Nematodes

A 
Ascaris lumbricoides
Trichuris trichuria 
Necator ancylostoma/americanus 
Strongyloids stercoralis 
Enterobius vermicularis 
Trichinela spiralis 
Trichostrongylus spp
Cutaneous larvae migrans
Angiostrongylus 
Wuchereria, Brugia, Loa loa 
Onchocerca volvulus 
Dracunculus 
Capillaria
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5
Q

MOA of albendazole

A

inhibits microtubule assembly, larvicidal and ovicidal

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6
Q

DOC for hydatid disease

A

albendazole

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7
Q

has improved penetration of subarachnoid space for neurocysticercosis

A

praziquantel

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8
Q

CI of albendazole

A

cirrhosis

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9
Q

selectively inhibits microtubule synthesis andf glucose uptake in nematodes
ovicidal

A

mebendazole

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10
Q

drug of choice for whipworm infections (Trichuris trichuria)

A

mebendazole

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11
Q

immobilizes microfilariae and alters their surface structure -> more susceptible to host defense mechanisms

A

diethylcarbamazepine

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12
Q

DOC filariasis

A

DEC

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13
Q

DEC when used for oncocerciasis may cause

A

Mazzotti reaction

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14
Q

can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and abdominal pain that occur within seven days of treatment of microfilariasis.

A

Mazzotti reactions

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15
Q

intensifies GABA mediated neutrotrabsmission in nematodes , immobilizes parasites

A

ivermectin

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16
Q

SE ivermectin

A

mazzotti rxn, corneal opacities

17
Q

sitmulates nicotinic receptors at NMJ of nematodes

causes depolarization induced paralysis

A

pyrantl pamoate

18
Q

DOC for pinworm(Entrobius vermicularis )

A

pyrantel pamoate

19
Q

will pyrantel pamoate kills eggs

A

no

20
Q

pyrantel pamoate CI

A

hepatic dysfunction

21
Q

Selectively inhibits microtubule synthesis and glucose uptaje in nematodes
inhibits fumarate reductase
ovidcidal

A

thiabendazole

Basic Pharmacology (15 decks)

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