2.3Lipoproteinemia Table

Question 1

Type I
Primary hyperchylomicronemia
cause

Answer 1

deficiency in LPL or

ApoC II

Question 2

Type II A
Familial hypercholesterolemia

cause

Answer 2

defect in LDL receptors

Question 3

Type IIB
Familial combined hypercholesterolemia

cause

Answer 3

overproduction of VLDL

Question 4

Type III
Familial dysbetaliproteinemia
cause

Answer 4

deficiency in ApoE

Question 5

Type IV
Familial dysbetalipoprotenemia
caue

Answer 5

deficiency in ApoE

Question 6

Type IV
familial hypertriglyceridemia
cause

Answer 6

decreased clearance of VLDL

Question 7

Type V
Familial combined hypertriglyceridemia
caused

Answer 7

decreased clearance of VLDL

Question 8

management
Primary hyperchylomicronemia
lipid profile

Answer 8

inc chylomicrons
inc triglycerides

1 - Low fat diet

2 - niacin + fibrate
NF

Question 9

Type II A
Familial hypercholesterolemia

mgt
lipid profile

Answer 9

inc LDL
normal VLDL

1 - statin
2 - niacin + ezetimibe

Question 10

Type III
Familial dysbetalipoprotenemia
tx
lipid profile

Answer 10

Inc VLDL remnants
Inc chylomicrons
1 - fibrate + niacin
2 - statin

Question 11

Type IV
familial hypertriglyceridemia
tx

lipid profile

Answer 11

inc TG
inc VLDL
dec / normal LDL

Fibrate + niacin

Question 12

Type V
familial combined hypertriglyceridemia
tx
lipid profile

Answer 12

Inc TG
inc chylomicrons 
inc VLDL 
dec / normal LDL
fibrate + niacin

Question 13

Type IIB
Familial combined hypercholesterolemia
mgt

Answer 13

depending on lipid profile
> inc VLDL
1 - statin
2 - Niacin + fibrate

> inc LDL
1 - statin
2 - niacin + ezetimibe

> inc VLDL, inc LDL
1 - statin
2 - niacin + ezetimibe