Antigens, Haptens and Immunogens Flashcards

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1
Q

what is an antigen ?

A

a substance that interacts with white blood cells or lymphocytes

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2
Q

what are immunogens ?

A

They are substance that generate immune response

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3
Q

what are haptens ?

A
  • small molecules that could never induce an immune system unless they are coupled with a carrier molecule (foreign protein)
  • hapten- carrier molecule can act as an immunogen
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4
Q

the binding of an antigen to an antibody is depending on …..

A
  1. ionic bonds
  2. electrostatic attractions
  3. Van der Waals attractions

antibody - antigen bond is reversible

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5
Q

what is an epitope?

A

small site on antigen that is recorgnized by the antibody in order for it to bind

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6
Q

whta is an antigen determinant ?

A

cluster of eptomes on the surgace of an antigen

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7
Q

Factor affecting immunogenicity contribution of the immunogen

A
  1. foreigness
  2. size
  3. chemical COMPOSITION
    * sequence determinants (primary structure)
    * conformational determinnts (secondary,tertiary,quaternary structure )
  4. physical form (particulate/soluble - dentured/native foreigness)
  5. degradability (Ag processing ny Ag processig cells/ APC)
  6. genetics (species/individual)
  7. Age
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8
Q

Factor affecting immunogenicity contribution of the immunogen (method of administration)

A
  1. Dose
  2. Route (subcutaneous,intravenous,intragastric)
  3. Adjuvant (substances that inhance the immune response of Ag)
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