Antibodies - structure & function Flashcards
1
Q
what is innate immunity ?
A
- nonspecific
- fast response (0-4hrs)
2
Q
what is adaptive immunity ?
A
- specific
- slow response (4-14 days)
3
Q
types of adaptive immunity ?
A
- T Helper cell
- B cells
- CD4+
4
Q
what are different names that mean antibody ?
A
- immunogloubulin
- gamma (y) globulin
- commonly abbreviated Ab or Ig
5
Q
5
what are the classes of antibodies ?
A
- IgA
- IgD (expressed in mature B-lymphocytes)
- IgE
- IgG (abundant in blood)
- IgM(expressed in mature B-lymphocytes)
6
Q
where are antibodies made ?
A
- activated by B-lymphocytes called plasma cells
- found in fluids and secretions
7
Q
what’s another name for antigen ?
A
Ag
8
Q
what are the structural features of an antibody ?
A
- heavy and light chains
- constsnt and variable regions
- antigen binding site
- Hinge
- Effector-binding sites
9
Q
what is an epitope and a paratope ?
A
names given to 3D surfaces which interact on the antigen and antibody respectively
10
Q
immune complex (IC)
A
AbAg
This is because both Ab and Ag may have several binding sites
11
Q
functions of antibodies
A
- neutralisation of toxins
- initiation of inflammation
- agglutilation of particular antigens
