Antigenic Determinants

Question 1

Name 3 antigenic determinants ON antibodies

Answer 1

Isotypic
Allotypic
Idiotypic

Question 2

Isotypic

Answer 2

Constant region of Ab

• Anti-Isotypic is activated if u inject antibody in diff species
• within same species, No anti-isotypic

Question 3

Allotypic

Answer 3

Form of polymorphisim

1 species+same isotypes= still small difference by (1-4a/a)

Question 4

If you get injected by such an Ab you will generate

Answer 4

Anti-allotype Ab
Ex. During pregnany or
Blood transfusion

Question 5

Idiotype

Answer 5

Unique Vh and V(light) binds to antigen but can also become an antigenic determinant

Question 6

If u inject same monoclonal Ab into genetically identical recipient then

Answer 6

Anti-idiotypic Ab are generated

Question 7

In idiotype the other antigenic determinants r not activated

Answer 7

Anti-isotypic
Anti-allotypic
Will NOT BE GENERATED

Question 8

Diagonostic test

Answer 8

Abs capable of detecting tiny amounts of molecules (pg/mL)

Ex. Pregnancy hormones

Question 9

Diagnostic imaging

Answer 9

mAbs that recognize tumor antigens are radiolabeled with iodine I-131

Question 10

Immunotoxins

Answer 10

mAbs conjugated with toxins