Antifungicos Flashcards

1
Q

Tipos de enfermedades producidas por hongos

A

Infestaciones superficiales cutaneas

Infecciones profundas

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2
Q

Enfermedades fungicas mas importantes

A

Candidiasis

Tinea cruris

Keratitis fungica

Apergilosis

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3
Q

Candidiasis

Cuasado por?

Y donde da

A

Por candida albicans

Lengua, carrillos, orofaringe, esofago

Piel

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4
Q

Tinea cruris

Como se trata?

Donde da

A

Axilas, area inguinal, genitales, region pubica, region perianal

Se trata con antifungicos topicos y orales

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5
Q

Keratitis fungica

Donde afecta

A

Ojo,esclera

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6
Q

Aspergilosis

Quien la causa

Donde da

A

Pulmones, tejido cerebral

Aspergillus

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7
Q

Anfotericina B

Mecanismos de acción

A

Se une al ergosterol, creando canales en la membrana celular, alterando la permeabilidad

Toxicidad porque se unen a colesterol de membrana humana

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8
Q

Absorción de anfotericina B

A

No se absorbe

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9
Q

Administración de anfotericina B

A

IV y topico

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10
Q

Excreción de anfotericina B

A

Se excreta 2 meses despues por el riñon

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11
Q

Nistatina

Mecanismo de acción

A

Se une a ergosterol de membrana celular creando canales, aumentando la permeabilidad

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12
Q

Absorción de nistatina

A

Poca gastrointestinal, poca en piel y mucosas

Se toma par candidiasis en esofago

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13
Q

Nistatina

Administración

A

Topica

Tomada

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14
Q

Azoles

A
  1. Ketoconazol
  2. Clotrimazol
  3. Itraconazol( mas utilizados)
  4. Voriconazol
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15
Q

Azoles

Mecanismo de acción

A

Inhiben la enzima encargada se la sintesis de ergosterol

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16
Q

Equinocandinas

Mecanismo de acción

A

Inhibición no competitiva de la sintesis de uniones de glucano

17
Q

Equinocandinas

A
  1. Caspofungina
  2. Micafungina
  3. Anidulafungina
18
Q

Familias de antimicoticos

A
  1. Anfotericina B
  2. Nistatina
  3. Azoles
  4. equinocandinas
  5. Griseofulvina