Anticorps Flashcards

1
Q

Vitesse de sédimentation normale en fonction de l’âge

A

Homme : âge / 2

Femme : age+10 / 2

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2
Q

Conditions autres que inflammation faisant augmenter VS

A
Anémie
Hypergammaglobulinémie
Néo
Trauma
Ischémmie
Syndrome néphrotique
Obésité
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3
Q

Conditions autres que inflammation faisant augmenter CRP

A

Obésité
Diabète
IRC

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4
Q

Causes de FR +

A
PAR (56%)
Sjogren (75-95%)
MCTD (50-60%)
Cryo (40-100%)
LED (15-35%)
PM/DM (5-10%)
Endocardite
Hépatite B/C
TB
Mono
Rubéole
influenza
Malaria
Syphilis
UIP
Sarcoidose
CBP
Hépatite autoimmuneàNÉoplasies
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5
Q

Vrai ou faux, RF associé à maladie érosive et manifestations extra-articulaires?

A

Vrai

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6
Q

Vrai ou faux, bénéfice à répéter Fr

A

Faux, change rarement

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7
Q

Sensibilité anti-CCP

A

67%

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8
Q

Spécificité anti-CCP

A

98%

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9
Q

Pourcentage de la population générale ayant un FR+

A

3-5%

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10
Q

Pourcentage de la population générale ayant un anti-CCP +

A

0,4%

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11
Q

Causes d’anti-CCP +

A
PAR
LED (9(%)
Sjogren (5%)
GPA (1%)
SpA (3%)
APso (8%)
Hépatite C (1%)
TB active
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12
Q

Vrai ou faux, FR et anti-CCP peuvent apparaissent plusieurs années avant PAR

A

Vrai

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13
Q

Causes de FAN +

A
LED (95%)
MCTD (99%)
Sclérodermie (60-80%)
Sjogren (40-70%)
Myosite (50-60%)
PAR (30%)
Vasculite rhumatoïde (50%)
Thyroidite Hashimoto (45%)
Graves (50%)
Hépatite autoimmune (50%)
XBP (10-40%)
HTAP (40%)
Infections chroniques
Néoplasies
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14
Q

Pourcentage de FAN + dans la population générale

A

1: 40 20-30%
1: 80 10%
1: 160 5%
1: 320 3%

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15
Q

Anticorps associés à FAN homogène

A
Anti-dsDNA
Anti-Histone
Anti-Scl70
Anti-Ku
* Aussi retrouvé dans PAR
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16
Q

Anticorps associé à FAN périphérique

A

Anti-dsDNA

17
Q

Anticorps associés à FAN moucheté

A
Anti-SSA
Anti-SSB
Anti-Sm
Anti-RNP
Anti-Scl70
Anti-ARN polymerase 3
Anti-Ku
Anti MI2
Anti-TIF1 gamma
Anti-NXP2
Anti-MDA5
Anti-SAE
Anti-PCNA
* Aussi retrouvé dans CBP
18
Q

Anticorps associés à FAN nucléaire

A
Anti-Scl70
Anti-ARN polymerase 3
Anti-Th/To
Anti-U3RNP
Anti-Ku
Anti-Pm-Scl
Anti-B23
19
Q

Anticorps associés à FAN centromère

A
Anti-CENP-B
Anti-CENP-A
Anti-CENP-C
Anti-CENP-D
(sclérodermie systémique limitée)
20
Q

Mx associées à ANCA atypiques (x-ANCA)

A
MII
Hépatite autoimmune
Cholangite sclérosante primitive
FKP
Collagénoses
Rx (PTU, méthimazole, hydralazine, minocycline, allopurinol, isoniazid, indomethacine, Levamizole)
21
Q

Pourcentage HLA B27+ selon la pathologie

A
SA 90-95%
Arthrite reactive 70-90%
APso 25%/axial 60%
Arthrite associé MII 10%/axial 70%
Population générale 8%